TY - JOUR AU - Viswanath, Biju AU - Rao, Naren P. AU - Narayanaswamy, Janardhanan C. AU - Sivakumar, Palanimuthu T. AU - Kandasamy, Arun AU - Kesavan, Muralidharan AU - Mehta, Urvakhsh Meherwan AU - Venkatasubramanian, Ganesan AU - John, John P. AU - Mukherjee, Odity AU - Purushottam, Meera AU - Kannan, Ramakrishnan AU - Mehta, Bhupesh AU - Kandavel, Thennarasu AU - Binukumar, B. AU - Saini, Jitender AU - Jayarajan, Deepak AU - Shyamsundar, A. AU - Moirangthem, Sydney AU - Vijay Kumar, K. G. AU - Thirthalli, Jagadisha AU - Chandra, Prabha S. AU - Gangadhar, Bangalore N. AU - Murthy, Pratima AU - Panicker, Mitradas M. AU - Bhalla, Upinder S. AU - Chattarji, Sumantra AU - Benegal, Vivek AU - Varghese, Mathew AU - Reddy, Janardhan Y. C. AU - Raghu, Padinjat AU - Rao, Mahendra AU - Jain, Sanjeev PY - 2018 DA - 2018/04/18 TI - Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science JO - BMC Psychiatry SP - 106 VL - 18 IS - 1 AB - There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, that cut across traditional diagnostic boundaries. With this background, the Discovery biology of neuropsychiatric syndromes (DBNS) proposes to recruit patients from five different syndromes (schizophrenia, bipolar disorder, obsessive compulsive disorder, Alzheimer’s dementia and substance use disorders), identify those with multiple affected relatives, and invite these families to participate in this study. The families will be assessed: 1) To compare neuro-endophenotype measures between patients, first degree relatives (FDR) and healthy controls., 2) To identify cellular phenotypes which differentiate the groups., 3) To examine the longitudinal course of neuro-endophenotype measures., 4) To identify measures which correlate with outcome, and 5) To create a unified digital database and biorepository. SN - 1471-244X UR - https://doi.org/10.1186/s12888-018-1674-2 DO - 10.1186/s12888-018-1674-2 ID - Viswanath2018 ER -