Table 1 Systematic data recorded during recruitment and two-yearly follow-ups in ADBS
Sociodemographic data | Age, gender, education, language, ethnicity/region of origin |
|---|---|
Brief assessments | Psychiatry clinical work-up sheet with history of the presenting illness, detailed assessment of the family pedigree, developmental history assessment and mental status examination. |
Medical history | |
History of previous medications – effects and adverse events | |
Physical examination | |
DSM V cross-cutting diagnostic assessment [73] | |
M.I.N.I. international neuropsychiatric interview (Version 5.0.0) [74] | |
Family interview for genetic studies (FIGS) [75] | |
Adult ADHD self-report scale (version 1.1) [76] | |
Hindi mental state examination (HMSE) [77] | |
Clinical global impression severity rating (CGI-S) [78] | |
Neurodevelopmental endophenotype assessments – clinical (general) | Adult temperament questionnaire [79] |
20 Item mini-IPIP [80] | |
Global assessment of functioning (GAF) [81] | |
Work and social adjustment scale (WSAS) [82] | |
Adverse childhood experiences international questionnaire (ACE-IQ) [83] | |
Interview for recent life events (IRLE) [84] | |
Kuppuswamy scale [85] | |
Edinburg handedness inventory [86] | |
Neurodevelopmental endophenotype baseline assessments – clinical (psychopathology specific) | Schedule for assessment of positive symptoms (SAPS) [87] |
Schedule for assessment of negative symptoms (SANS) [88] | |
Young’s mania rating scale (YMRS) [89] | |
Hamilton depression rating scale (HDRS) [90] | |
Hamilton anxiety rating scale (HARS) [91] | |
Yale-Brown obsessive compulsive scale [92] | |
Clinical dementia rating Scale [93] | |
Neurodevelopmental endophenotype assessments – cognitive | Digit Forward Span (attention and concentration) [94] |
Color trails 1 (processing speed) [95] | |
Verbal N Back 1&2 (working memory) [96] | |
Color trails 2 (cognitive flexibility) [95] | |
Stop signal task (response inhibition) [97] | |
Rey-Osterrieth Auditory Verbal Learning Test (verbal learning and memory) [98] | |
2nd order theory of mind stories (theory of mind) [99] | |
Neurodevelopmental endophenotype assessments – neuroimaging | T1-weighted structural magnetic resonance imaging (MRI) |
Structural White Matter- Diffusion Tensor Imaging (DTI) using an echo planar imaging sequence | |
Rest-functional MRI | |
Task-functional MRI: word generation [33] | |
Neurodevelopmental endophenotype assessments – psychophysics & clinical electrophysiology | Eye-tracking studies – saccade experiments [101] and smooth pursuit eye movement (SPEM) experiments [102] |
Functional Near Infrared Spectroscopy (fNIRS): resting state and during cognitive experiments (tower of London task [103] & facial emotion processing task) | |
Electroencephalography – resting state [35] and P50-suppression [104] |