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Table 1 Systematic data recorded during recruitment and two-yearly follow-ups in ADBS

From: Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science

Sociodemographic data Age, gender, education, language, ethnicity/region of origin
Brief assessments Psychiatry clinical work-up sheet with history of the presenting illness, detailed assessment of the family pedigree, developmental history assessment and mental status examination.
Medical history
History of previous medications – effects and adverse events
Physical examination
DSM V cross-cutting diagnostic assessment [73]
M.I.N.I. international neuropsychiatric interview (Version 5.0.0) [74]
Family interview for genetic studies (FIGS) [75]
Adult ADHD self-report scale (version 1.1) [76]
Hindi mental state examination (HMSE) [77]
Clinical global impression severity rating (CGI-S) [78]
Neurodevelopmental endophenotype assessments – clinical (general) Adult temperament questionnaire [79]
20 Item mini-IPIP [80]
Global assessment of functioning (GAF) [81]
Work and social adjustment scale (WSAS) [82]
Adverse childhood experiences international questionnaire (ACE-IQ) [83]
Interview for recent life events (IRLE) [84]
Kuppuswamy scale [85]
Edinburg handedness inventory [86]
Neurodevelopmental endophenotype baseline assessments – clinical (psychopathology specific) Schedule for assessment of positive symptoms (SAPS) [87]
Schedule for assessment of negative symptoms (SANS) [88]
Young’s mania rating scale (YMRS) [89]
Hamilton depression rating scale (HDRS) [90]
Hamilton anxiety rating scale (HARS) [91]
Yale-Brown obsessive compulsive scale [92]
Clinical dementia rating Scale [93]
Neurodevelopmental endophenotype assessments – cognitive Digit Forward Span (attention and concentration) [94]
Color trails 1 (processing speed) [95]
Verbal N Back 1&2 (working memory) [96]
Color trails 2 (cognitive flexibility) [95]
Stop signal task (response inhibition) [97]
Rey-Osterrieth Auditory Verbal Learning Test (verbal learning and memory) [98]
2nd order theory of mind stories (theory of mind) [99]
Neurodevelopmental endophenotype assessments – neuroimaging T1-weighted structural magnetic resonance imaging (MRI)
Structural White Matter- Diffusion Tensor Imaging (DTI) using an echo planar imaging sequence
Rest-functional MRI
Task-functional MRI: emotion processing [31, 100]
Task-functional MRI: word generation [33]
Neurodevelopmental endophenotype assessments – psychophysics & clinical electrophysiology Eye-tracking studies – saccade experiments [101] and smooth pursuit eye movement (SPEM) experiments [102]
Functional Near Infrared Spectroscopy (fNIRS): resting state and during cognitive experiments (tower of London task [103] & facial emotion processing task)
Electroencephalography – resting state [35] and P50-suppression [104]