TY - JOUR AU - Bhardwaj, Anjali K. AU - Allsop, David J. AU - Copeland, Jan AU - McGregor, Iain S. AU - Dunlop, Adrian AU - Shanahan, Marian AU - Bruno, Raimondo AU - Phung, Nghi AU - Montebello, Mark AU - Sadler, Craig AU - Gugusheff, Jessica AU - Jackson, Melissa AU - Luksza, Jennifer AU - Lintzeris, Nicholas AU - Chan, Therese AU - Jago, Betty AU - McKendrick, Lynsey AU - Rivas, Consuelo AU - Schwanz, Ricardo AU - Yang, Abigail AU - Zavareh, Zachary AU - Hall, Michelle AU - Hazelwood, Susan AU - Winmill, Anthony AU - Barbaro, Angelo AU - Black, Kerin AU - Ho, Tim AU - Jefferies, Meryem AU - Jule, Jonathon Coreas AU - Nagubandi, Shyam AU - Shahidi, Mahsa AU - Snell, Catherine Silsbury Lisa AU - Wijanto, Matthew AU - Agonist Replacement for Cannabis Dependence (ARCD) study group PY - 2018 DA - 2018/05/18 TI - Randomised Controlled Trial (RCT) of cannabinoid replacement therapy (Nabiximols) for the management of treatment-resistant cannabis dependent patients: a study protocol JO - BMC Psychiatry SP - 140 VL - 18 IS - 1 AB - The cannabis extract nabiximols (Sativex®) effectively supresses withdrawal symptoms and cravings in treatment resistant cannabis dependent individuals, who have high relapse rates following conventional withdrawal treatments. This study examines the efficacy, safety and cost-effectiveness of longer-term nabiximols treatment for outpatient cannabis dependent patients who have not responded to previous conventional treatment approaches. SN - 1471-244X UR - https://doi.org/10.1186/s12888-018-1682-2 DO - 10.1186/s12888-018-1682-2 ID - Bhardwaj2018 ER -