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Table 2 Differences between different factors of anxiety/depression and non-anxiety/depression patients

From: Anxiety and depression in primary Sjögren’s syndrome: a cross-sectional study

Clinical characteristics non-anxiety Anxiety p non-depression depression p
Age, mean ± sd yearsa 50.08 ± 11.90 51.44 ± 12.90 0.508 49.69 ± 11.96 51.12 ± 12.68 0.228
Gender, female, no. (%)b 100(94.3) 55 (96.3) 0.878 97(96) 55 (93.2) 0.679
Marital status, no. (%)b    1.000    0.401
 Married 100 (94.3) 51 (94.4)   97 (96) 54 (91.5)  
 Other marital status 6 (5.7) 3 (5.6)   4 (4) 5 (8.5)
Education, years, no. (%)a 12.43 ± 4.42 11.72 ± 4.16 0.327 13.00 ± 3.96 10.81 ± 4.62 0.002*
Employment status, no. (%)b    0.064    0.049*
 Employed 53 (50) 18 (33.3)   51 (50.5) 20 (33.9)  
 Unemployed 53 (50) 36 (66.7)   50 (49.5) 39 (66.1)
Income/person/year, yuan, no. (%)b    0.423    0.094
  < 15,000 yuan 34 (32.1) 21 (38.9)   31 (30.7) 24 (40.7)  
 15,000-33,000 yuan 36 (34) 13 (24.1)   37 (36.6) 12 (20.3)
  ≥ 33,000 yuan 36 (34) 20 (37)   33 (32.7) 23 (39)
Type of medical insurance, n (%)b    0.749    0.660
 With basic medical insurance 96 (90.6) 50 (92.6)   91 (90.1) 55 (93.2)  
 Self-pay 9 (8.5) 4 (7.4)   9 (8.9) 4 (6.8)
 Other 1 (0.9) 0 (0)   1 (1) 0 (0)
Disease duration, mean ± sd yearsa 4.48 ± 5.61 4.53 ± 5.15 0.957 4.30 ± 4.72 4.83 ± 6.53 0.557
VAS pain (range 0–10), mean ± sda 2.12 ± 2.51 2.83 ± 2.98 0.127 2.35 ± 1.95 3.07 ± 2.99 0.016*
ESR, mean ± sd mm/ha 28.10 ± 21.38 35.87 ± 28.47 0.085 27.10 ± 20.04 36.78 ± 29.10 0.027*
OSDI, mean ± sda 25.07 ± 22.40 37.15 ± 28.28 0.008* 23.82 ± 20.81 38.26 ± 29.14 0.001*
RF positivity, yes, no. (%)b 29 (46) 22 (55) 0.422 30 (49.2) 21 (50) 1.000
Hospitalization, yes, n (%)b 68 (64.2) 40 (74.1) 0.218 68 (67.3) 40 (67.8) 1.000
Family history, yes, n (%)b 15 (14.2) 8 (14.8) 1.000 17 (16.8) 6 (10.2) 0.351
Comorbid conditions, yes, n (%)b 66 (62.3) 36 (66.7) 0.607 61 (60.4) 41 (69.5) 0.307
ESSDAIa 9.16 ± 7.73 10.48 ± 6.37 0.281 8.73 ± 7.35 11.10 ± 7.03 0.047*
IgG (g/L)a 19.05 ± 6.72 18.72 ± 6.60 0.806 18.99 ± 6.54 18.84 ± 6.85 0.909
C3 (g/L)a 0.80 ± 0.26 0.82 ± 0.28 0.781 0.80 ± 0.24 0.82 ± 0.30 0.632
C4 (g/L)a 0.18 ± 0.07 0.17 ± 0.06 0.627 0.18 ± 0.66 0.17 ± 0.06 0.552
ANA ≥1: 320b 61 (91) 35 (92.1) 1.000 60 (93.8) 36 (87.8) 0.481
Anti-SSA ≥ 200 RU/mLb 54 (80.6) 31 (81.6) 1.000 50 (78.1) 35 (85.4) 0.449
Anti-SSB ≥ 20 RU/mLb 32 (47.8) 21 (55.3) 0.544 29 (45.3) 24 (58.5) 0.231
  1. VAS visual analog scale, ESR erythrocyte sedimentation rate, RF rheumatoid factor, HADS hospital anxiety and depression scale, ESSDAI EULAR Sjögren’s syndrome disease activity index, ANA antinuclear antibodies, IgG immunoglobulin G, C3 complement C3, C4 complement C4, OSDI the ocular surface disease index.* = p<0.05; a = t-tests; b = χ2 analyses