Fig. 5
Top-ranked pathways associated with quantitative behavioral traits. Results for mice (a–g) and dogs (h) are shown. a Fear conditioning (FC) cue test. b FC context test. c Prepulse inhibition (PPI). d Elevated plus maze. e Forced swim test. f Sleep duration in 24 h. g Differences in sleep length in light (L) and dark (D) periods. h Fear of noise in dogs. Dashed red lines represent Bonferroni-corrected significance thresholds. Groups of pathways belonging to different classes are labeled with colored texts. ABC, ATP-binding cassette; Activ., activation/activates; alkyl., alkylation; assemb., assembly; biol., biology; biosynth., biosynthesis; catab., catabolism; Cdk, cyclin-dependent kinase; cell., cellular; CL, cardiolipin; clear., clearance; cleav., cleavage; cmplx., complex; cont., containing; demethyl., demethylates; devel., development/developmental; DSCAM, Down syndrome cell adhesion molecule; enab., enables; EPH, erythropoietin-producing human hepatocellular receptor; ER, endoplasmic reticulum; exec., execution; expr., expression; FA, fatty acid; facilit., facilitative; FZD, frizzled protein; gCOO, γ-carboxylation/carboxylated; glycosyl., glycosylation; GPCR, G protein-coupled receptor; homeo., homeostasis; IFN, interferon; IL, interleukin; ind., induces/induced; indep., independent; inhib., inhibition/inhibits; inter., interaction; interconv., interconversion; intermed., intermediate; ISG15, interferon-stimulated gene 15; LPC, lysophosphatidylcholine; LRRFIP1, leucine-rich repeat flightless-interacting protein 1; MAPK, mitogen-activated protein kinase; mech., mechanism; med., mediated; metab., metabolism; misc., miscellaneous; neg., negative; NFkB, nuclear factor kappa B; NLRP, NACHT, LRR and PYD domains-containing protein; oxidat., oxidation; PAO, polyamine oxidase; phosph., phosphorylation; PI, phosphatidylinositol; PIP2, phosphatidylinositol phosphate 2; pol I, polymerase I; prog., programmed; propept., propeptide; prot., protein; R., receptor/receptors; Rap, Ras-related protein; reg., regulation/regulates; remod., remodeling; remov., removal; repl., replication; resp., response; RSK, ribosomal 6 kinase; rxn., reaction; sig., signal/signaling; stimul., stimulation; synap., synaptic; synth., synthesis; sys., system; TDG, thymine-DNA glycosylase; term., terminal/terminates/termination; TET, ten-eleven translocation methylcytosine dioxygenase; TFAP, transcription factor activating enhancer binding protein; TNFR, tumor necrosis factor R; transcr., transcription; transm., transmembrane; transp., transports/transporter/transportation; TSR, thrombospondin repeat; ubiquit., ubiquitination; UFA, unsaturated fatty acid