Fig. 8

Broad-sense heritability of pathways compared to proportion of additive variance explained. a Fear conditioning (cue test) in mice. b Prepulse inhibition (PPI) in mice. The top-ranked pathways in Fig. 5a,c are shown in the same order. CDA values represent r² estimated using regularization conditions determined from cross-validation applied to half of the whole cohort and repeating the inference for the other half. Error bars represent the 95% c.i. The GCTA and LDAK outcomes represent the proportion of variance explained by the same set of SNPs but without interaction effects. For pathways in which the GCTA/LDAK p-values were higher than 0.05, the proportion of variance was set to zero. The CDA p-values are all smaller than 10⁻³ (Fig. 5)