intervention guroup | control group | Defference(95% CI) | P Value | |||
---|---|---|---|---|---|---|
Family members | ||||||
Questionnaire, LS mean (95% CI) | ||||||
K6 | 8 W | 4.27 (2.78 to 5.77) | 5.33 (3.96 to 6.71) | −1.05 (−2.68 to 0.56) | 0.19 | |
16 W | 5.65 (4.06 to 7.23) | 4.47 (2.97 to 5.98) | 1.17 (−0.63 to 2.98) | 0.19 | ||
32 W | 4.82 (3.23 to 6.41) | 4.34 (2.85 to 5.83) | 0.48 (−1.32 to 2.29) | 0.59 | ||
BDI-II | 8 W | 7.36 (3.98 to 10.75) | 10.74 (7.61 to 13.86) | −3.37 (−6.32 to − 0.43) | 0.02 | |
16 W | 8.49 (4.54 to 12.45) | 10.34 (6.72 to 13.96) | −1.84 (−6.03 to 2.34) | 0.37 | ||
32 W | 9.36 (5.19 to 13.53) | 8.41 (4.53 to 12.28) | 0.94 (−3.66 to 5.55) | 0.67 | ||
J-ZBI_8 | 8 W | 7.35 (5.39 to 9.31) | 6.14 (4.33 to 7.95) | 1.21 (−0.94 to 3.36) | 0.26 | |
16 W | 7.06 (4.88 to 9.25) | 5.21 (3.10 to 7.32) | 1.85 (−0.73 to 4.44) | 0.15 | ||
32 W | 5.93 (3.57 to 8.30) | 4.04 (1.77 to 6.31) | 1.89 (−0.97 to 4.76) | 0.18 | ||
FAS | 8 W | 41.19 (30.22 to 52.17) | 41.25 (31.08 to 51.42) | −0.05 (−10.84 to 10.72) | 0.99 | |
16 W | 41.33 (29.60 to 53.07) | 37.18 (26.31 to 48.05) | 4.15 (−8.26 to 16.58) | 0.50 | ||
32 W | 39.86 (28.49 to 51.22) | 32.36 (22.04 to 42.68) | 7.49 (−4.18 to 19.17) | 0.20 | ||
patient | ||||||
Questionnaire, LS mean (95%CI) | ||||||
BDI-II | 8 W | 21.61 (17.50 to 25.72) | 23.51 (19.32 to 27.70) | −1.91(−7.85 to 4.05) | 0.52 | |
16 W | 19.98 (15.86 to 24.09) | 21.67 (17.62 to 25.72) | −1.69 (−7.55 to 4.16) | 0.56 | ||
32 W | 19.14 (15.19 to 23.09) | 20.34 (16.32 to 24.36) | −1.19 (−6.89 to 4.50) | 0.67 | ||
FAD | PS | 8 W | 2.33 (2.19 to 2.46) | 2.46 (2.33 to 2.60) | −0.13(−0.33 to 0.05) | 0.16 |
16 W | 2.33 (2.17 to 2.49) | 2.41 (2.24 to 2.57) | −0.07 (− 0.3 to 0.15) | 0.52 | ||
32 W | 2.15 (2.00 to 2.31) | 2.33 (2.16 to 2.49) | −0.17 (− 0.40 to 0.05) | 0.13 | ||
CM | 8 W | 2.31 (2.19 to 2.43) | 2.33 (2.20 to 2.45) | −0.01(− 0.19 to 0.15) | 0.82 | |
16 W | 2.29 (2.17 to 2.41) | 2.33 (2.21 to 2.45) | −0.04 (− 0.21 to 0.13) | 0.63 | ||
32 W | 2.25 (2.11 to 2.39) | 2.22 (2.08 to 2.37) | 0.02 (−0.17 to 0.22) | 0.79 | ||
RL | 8 W | 2.01 (1.92 to 2.10) | 2.14 (2.05 to 2.23) | −0.13(− 0.26 to − 0.00) | 0.04 | |
16 W | 1.99 (1.87 to 2.11) | 2.09 (1.97 to 2.21) | −0.09 (− 0.27 to 0.07) | 0.25 | ||
32 W | 2.00 (1.90 to 2.10) | 2.07 (1.97 to 2.18) | −0.07 (− 0.22 to 0.07) | 0.33 | ||
AR | 8 W | 2.17 (2.04 to 2.30) | 2.42 (2.28 to 2.55) | −0.24(− 0.43 to − 0.05) | 0.01 | |
16 W | 2.13 (1.98 to 2.28) | 2.30 (2.15 to 2.45) | −0.16 (− 0.38 to 0.04) | 0.12 | ||
32 W | 2.12 (1.99 to 2.25) | 2.34 (2.21 to 2.48) | −0.22 (− 0.41 to − 0.03) | 0.02 | ||
AI | 8 W | 2.22 (2.06 to 2.33) | 2.31 (2.18 to 2.45) | −0.11(− 0.30 to 0.07) | 0.22 | |
16 W | 2.14 (2.00 to 2.27) | 2.21 (2.07 to 2.35) | −0.07 (− 0.27 to 0.12) | 0.43 | ||
32 W | 2.11 (1.98 to 2.24) | 2.21 (2.08 to 2.34) | −0.09 (− 0.28 to 0.08) | 0.28 | ||
BC | 8 W | 2.09 (1.97 to 2.20) | 2.25 (2.13 to 2.36) | −0.15(− 0.32 to 0.00) | 0.05 | |
16 W | 2.10 (1.98 to 2.22) | 2.27 (2.15 to 2.39) | −0.17 (− 0.34 to − 0.00) | 0.04 | ||
32 W | 2.08 (1.96 to 2.20) | 2.23 (2.11 to 2.36) | −0.15 (− 0.32 to 0.01) | 0.07 | ||
GF | 8 W | 2.10 (1.99 to 2.20) | 2.18 (2.07 to 2.29) | −0.08(− 0.24 to 0.07) | 0.28 | |
16 W | 2.09 (1.94 to 2.25) | 2.16 (2.00 to 2.31) | −0.06 (− 0.28 to 0.15) | 0.56 | ||
32 W | 1.99 (1.84 to 2.13) | 2.05 (1.89 to 2.20) | −0.05 (− 0.27 to 0.15) | 0.58 | ||
SF-36 | PCS | 8 W | 45.48 (41.64 to 49.32) | 46.79 (42.81 to 50.77) | −1.30(−6.87 to 4.26) | 0.63 |
16 W | 43.35 (39.97 to 46.72) | 44.14 (40.71 to 47.57) | −0.79 (−5.66 to 4.06) | 0.74 | ||
32 W | 46.28 (43.48 to 49.08) | 44.91 (41.99 to 47.83) | 1.36 (−2.71 to 5.44) | 0.50 | ||
MCS | 8 W | 43.01 (39.61 to 46.42) | 40.36 (36.84 to 43.88) | 2.65(−2.29 to 7.60) | 0.28 | |
16 W | 46.25 (43.37 to 49.13) | 44.58 (41.66 to 47.51) | 1.66 (− 2.51 to 5.83) | 0.42 | ||
32 W | 45.54 (41.27 to 49.81) | 45.20 (40.76 to 49.65) | 0.33 (−5.85 to 6.52) | 0.91 | ||
Medications, LS mean (95%CI), DDD | ||||||
Antidepressants | 8 W | 1.66 (1.51 to 1.81) | 1.70 (1.55 to 1.85) | −0.03 (−0.24 to 0.17) | 0.74 | |
16 W | 1.69 (1.50 to 1.87) | 1.65 (1.46 to 1.84) | 0.04 (−0.22 to 0.30) | 0.76 | ||
32 W | 1.38 (1.13 to 1.64) | 1.47 (1.21 to 1.73) | −0.08 (− 0.45 to 0.27) | 0.63 | ||
Antianxiety | 8 W | 0.19 (0.12 to 0.26) | 0.12 (0.04 to 0.19) | 0.06 (−0.03 to 0.17) | 0.18 | |
16 W | 0.19 (0.12 to 0.26) | 0.12 (0.04 to 0.19) | 0.06 (−0.03 to 0.17) | 0.18 | ||
32 W | 0.15 (0.08 to 0.22) | 0.15 (0.08 to 0.22) | 0.00 (−0.10 to 0.10) | 0.98 | ||
Hypnotics | 8 W | 0.51 (0.31 to 0.72) | 0.70 (0.49 to 0.91) | −0.18 (− 0.48 to 0.11) | 0.21 | |
16 W | 0.51 (0.29 to 0.73) | 0.64 (0.41 to 0.87) | −0.12 (− 0.45 to 0.19) | 0.43 | ||
32 W | 0.39 (0.16 to 0.63) | 0.68 (0.44 to 0.92) | −0.28 (− 0.63 to 0.05) | 0.09 |