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Table 2 Time course of disease severity, global functioning, subjective wellbeing, and attitudes toward antipsychotic medication

From: Subjective well-being, drug attitude, and changes in symptomatology in chronic schizophrenia patients starting treatment with new-generation antipsychotic medication

  

Observation time

Comparison (Repeated measures ANOVA)

Baseline

(0)

Week 2

(1)

Week 4

(2)

Week 12

(3)

Overall

(0) vs. (1)

(0) vs. (2)

(0) vs. (3)

Mean

SD

Mean

SD

Mean

SD

Mean

SD

F

p-value

p-value

p-value

p-value

PANSS total score

59.71

16.51

56.40

15.36

53.07↓

15.90

52.33↓

14.41

6.10

0.001

0.078

0.003

0.001

PANSS positive

12.13

5.14

10.63↓

3.83

9.80↓

3.34

9.53↓#

3.07

9.02

< 0.001

0.015

0.001

0.001

PANSS negative

17.00

7.07

17.03

6.87

16.30

7.09

16.17

7.47

0.53

0.629

0.964

0.493

0.333

PANSS general

30.58

8.12

28.74↓

7.36

26.97↓

7.11

26.63↓#

6.15

7.81

< 0.001

0.042

0.001

0.001

GAF

56.67

16.40

59.03

15.34

62.43↑x

16.46

61.52↑

17.36

5.80

0.004

0.078

0.004

0.011

SWN-K total

- a

- a

83.45

18.63

85.91

17.92

87.56

17.14

1.47

0.253

- a

0.984b

0.512b

SWN-K mental

- a

- a

16.47

5.19

17.14

4.41

17.43

3.87

1.85

0.173

- a

0.190b

0.121b

SWN-K self-control

- a

- a

15.03

3.61

16.08

3.89

16.00

4.35

1.94

0.156

- a

0.072b

0.139b

SWN-K emotional

- a

- a

17.63

5.08

17.93

4.80

18.53

4.51

1.58

0.217

- a

0.621b

0.088 b

SWN-K physical

- a

- a

17.47

4.70

17.23

4.45

17.94

4.51

0.70

0.476

- a

0.744b

0.470b

SWN-K spcial

- a

- a

16.87

4.68

17.53

4.49

17.69

4.25

1.31

0.276

- a

0.115b

0.209 b

DAI total score

- a

- a

79.93

16.31

81.83

15.88

79.93

16.34

0.29

0.747

- a

0.528b

0.999 b

DAI positive

- a

- a

70.83

29.60

71.13

33.49

71.67

33.79

0.02

0.975

- a

0.937 b

0.844 b

DAI negative

- a

- a

18.33

31.36

15.56

26.60

21.39

28.17

0.94

0.397

- a

0.524 b

0.499 b

DAI illness-related

- a

- a

33.89

35.15

27.78

34.00

23.33↓

32.93

3.00

0.061

- a

0.118 b

0.032 b

DAI doctor

- a

- a

93.33

21.71

91.67

23.06

91.38

23.41

0.49

0.570

- a

0.326 b

0.330 b

DAI control

- a

- a

8.33

26.53

6.67

25.37

11.67

28.42

2.45

0.110

- a

0.326 b

0.161 b

DAI prevention

- a

- a

91.67

26.53

90.00

30.51

93.10

25.79

0.59

0.489

- a

0.663 b

0.343 b

DAI harm

- a

- a

28.33

38.69

25.00

36.55

28.33

38.69

0.44

0.649

- a

0.423b

0.999 b

  1. PANSS = Positive and Negative Syndrome Scale; GAF = Global Assessment of Functioning Scale; SWN-K = Subjective Well-being under Neuroleptic Treatment Scale, short form, DAI = Drug Attitude Inventory
  2. ↓ Significantly lower than at baseline
  3. ↑ Significantly higher than at baseline
  4. #Significantly lower than at week 2
  5. xSignificantly higher than at week 2
  6. aNot assessed at day 0
  7. bComparison with day 14