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Table 2 Time course of disease severity, global functioning, subjective wellbeing, and attitudes toward antipsychotic medication

From: Subjective well-being, drug attitude, and changes in symptomatology in chronic schizophrenia patients starting treatment with new-generation antipsychotic medication

   Observation time Comparison (Repeated measures ANOVA)
Baseline
(0)
Week 2
(1)
Week 4
(2)
Week 12
(3)
Overall (0) vs. (1) (0) vs. (2) (0) vs. (3)
Mean SD Mean SD Mean SD Mean SD F p-value p-value p-value p-value
PANSS total score 59.71 16.51 56.40 15.36 53.07 15.90 52.33 14.41 6.10 0.001 0.078 0.003 0.001
PANSS positive 12.13 5.14 10.63 3.83 9.80 3.34 9.53# 3.07 9.02 < 0.001 0.015 0.001 0.001
PANSS negative 17.00 7.07 17.03 6.87 16.30 7.09 16.17 7.47 0.53 0.629 0.964 0.493 0.333
PANSS general 30.58 8.12 28.74 7.36 26.97 7.11 26.63# 6.15 7.81 < 0.001 0.042 0.001 0.001
GAF 56.67 16.40 59.03 15.34 62.43x 16.46 61.52 17.36 5.80 0.004 0.078 0.004 0.011
SWN-K total - a - a 83.45 18.63 85.91 17.92 87.56 17.14 1.47 0.253 - a 0.984b 0.512b
SWN-K mental - a - a 16.47 5.19 17.14 4.41 17.43 3.87 1.85 0.173 - a 0.190b 0.121b
SWN-K self-control - a - a 15.03 3.61 16.08 3.89 16.00 4.35 1.94 0.156 - a 0.072b 0.139b
SWN-K emotional - a - a 17.63 5.08 17.93 4.80 18.53 4.51 1.58 0.217 - a 0.621b 0.088 b
SWN-K physical - a - a 17.47 4.70 17.23 4.45 17.94 4.51 0.70 0.476 - a 0.744b 0.470b
SWN-K spcial - a - a 16.87 4.68 17.53 4.49 17.69 4.25 1.31 0.276 - a 0.115b 0.209 b
DAI total score - a - a 79.93 16.31 81.83 15.88 79.93 16.34 0.29 0.747 - a 0.528b 0.999 b
DAI positive - a - a 70.83 29.60 71.13 33.49 71.67 33.79 0.02 0.975 - a 0.937 b 0.844 b
DAI negative - a - a 18.33 31.36 15.56 26.60 21.39 28.17 0.94 0.397 - a 0.524 b 0.499 b
DAI illness-related - a - a 33.89 35.15 27.78 34.00 23.33 32.93 3.00 0.061 - a 0.118 b 0.032 b
DAI doctor - a - a 93.33 21.71 91.67 23.06 91.38 23.41 0.49 0.570 - a 0.326 b 0.330 b
DAI control - a - a 8.33 26.53 6.67 25.37 11.67 28.42 2.45 0.110 - a 0.326 b 0.161 b
DAI prevention - a - a 91.67 26.53 90.00 30.51 93.10 25.79 0.59 0.489 - a 0.663 b 0.343 b
DAI harm - a - a 28.33 38.69 25.00 36.55 28.33 38.69 0.44 0.649 - a 0.423b 0.999 b
  1. PANSS = Positive and Negative Syndrome Scale; GAF = Global Assessment of Functioning Scale; SWN-K = Subjective Well-being under Neuroleptic Treatment Scale, short form, DAI = Drug Attitude Inventory
  2. Significantly lower than at baseline
  3. Significantly higher than at baseline
  4. #Significantly lower than at week 2
  5. xSignificantly higher than at week 2
  6. aNot assessed at day 0
  7. bComparison with day 14