Inclusion Criteria | Exclusion Criteria |
---|---|
Between ages 18–85 | Already taking statins (at least 6 weeks prior to screening) |
Bipolar Diagnosis in any phase of illness: euthymic, depressed or hypomanic. Any schizoaffective diagnosis. | History of adverse reaction to statins; allergy to statins |
Diagnosed with NDI, defined by routine 10 h water restriction urine osmolality < 600 mOsm/Kg | Contraindications to statin use: pregnancy or lactation, use of fibrates and heavy alcohol use |
Currently taking lithium medication (at least 2Â months) | Inability to give consent or deemed to have moderate-severe cognitive disturbances by treating clinician |
Able and willing to give informed consent | Active liver disease |
Baseline LDL level < 1.5 |