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Table 1 Clinical Staging Framework for Mental Health Disorders [4]

From: Youth at-risk for serious mental illness: methods of the PROCAN study

Stage

Definition

0

No clinical symptoms

• Increased risk of disorder (family history)

1a

Distress Disorder

• No attenuated psychotic symptoms

• Non-specific symptoms of anxiety or depression

• Mild to moderate severity of symptoms

• May include subjective/objective evidence of mild cognitive deficits.

• Evidence of only recent or mild impacts of illness on social, educational or occupational function

1b

Attenuated Syndromes

• Distress disorder plus at least one moderate-severe attenuated psychotic symptom (unusual thoughts, suspiciousness, perceptual abnormalities, grandiosity, disorganization)

• Specific symptoms of anxiety or depression, brief hypomania or brief psychotic phenomena

• May include subjective/objective evidence of at least moderate cognitive change

• Moderate to severe impact of illness on social, education or employment functioning

2

Discrete Disorders

• Discrete episodes of psychosis, mania or severe depression

• Full threshold disorder with moderate-severe symptoms and persistence over time

• Illness is having a major impact on social, educational or occupational functioning

3a-3c

4

Stages not Relevant for this Project

Incomplete remission to multiple relapses

Unremitting course of illness