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Table 2 Allelic distributions of the 14 SNPs and their associations with schizophrenia

From: Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study

  Case (n=310) Control (n=313) p Value2
SNP Allele1 Genotype No. Frequency No. Frequency Allele1 Codominant (AA/aa,Aa/aa,AA/Aa)3 Recessive Dominant Overdominant
rs4140535        0.725 0.806 1.000 0.729 0.909 0.684 0.764
  T   394 0.635 391 0.625        
   CC 44 0.142 46 0.147        
   CT 138 0.445 143 0.457        
   TT 128 0.413 124 0.396        
rs1778258        0.585 1.000 1.000 0.541 1.000 0.552 0.542
  G   556 0.897 555 0.887        
   AA 4 0.013 4 0.013        
   AG 56 0.181 63 0.201        
   GG 250 0.806 246 0.786        
rs17273700        0.423 0.772 0.377 0.185 0.576 0.279 0.184
  T   554 0.894 550 0.879        
   CC 7 0.023 5 0.016        
   CT 52 0.168 66 0.211        
   TT 251 0.810 242 0.773        
rs1228814        1.000 0.374 0.247 0.465 0.276 0.663 0.356
  C   517 0.834 522 0.834        
   AA 13 0.042 8 0.026        
   AC 77 0.248 88 0.281        
   CC 220 0.710 217 0.693        
rs11568817        0.315 1.000 1.000 0.254 1.000 0.271 0.255
  T   559 0.902 553 0.883        
   GG 5 0.016 5 0.016        
   GT 51 0.165 63 0.201        
   TT 254 0.819 245 0.783        
rs130058        0.916 0.686 0.816 0.434 1.000 0.449 0.816
  T   49 0.079 48 0.077        
   AA 265 0.855 267 0.853        
   AT 41 0.132 44 0.141        
   TT 4 0.013 2 0.006        
rs6297        0.409 0.599 0.786 0.565 0.788 0.460 0.816
  A   541 0.873 536 0.856        
   AA 237 0.765 231 0.738        
   AG 67 0.216 74 0.236        
   GG 6 0.019 8 0.026        
rs3827804        0.802 0.800 0.800 0.800
  A   8 0.013 7 0.011        
   AG 8 0.026 7 0.022        
   GG 302 0.974 306 0.978        
   AA 0 0.000 0 0.000        
rs140792648        0.862 0.860 0.860 0.860
   604 0.974 608 0.971        
   —/— 294 0.948 295 0.942        
   —/AG 16 0.052 18 0.058        
   AG/AG 0 0.000 0 0.000        
rs9361234        0.408 1.000 1.000 0.348 1.000 0.364 0.349
  C   559 0.902 555 0.887        
   CC 254 0.819 247 0.789        
   CT 51 0.165 61 0.195        
   TT 5 0.016 5 0.016        
rs183156887        1.000 1.000 1.000 1.000
  A   4 0.006 4 0.006        
   AC 4 0.013 4 0.013        
   CC 306 0.987 309 0.987        
   AA 0 0.000 0 0.000        
rs76194807        0.486 0.725 0.242 0.472 0.340 0.725 0.242
  T   79 0.127 71 0.113        
   GG 234 0.755 247 0.789        
   GT 73 0.235 61 0.195        
   TT 3 0.010 5 0.016        
rs58138557        0.411 1.000 1.000 0.351 1.000 0.367 0.352
  GG   558 0.900 554 0.885        
   —/— 5 0.016 5 0.016        
   —/GG 52 0.168 62 0.198        
   GG/GG 253 0.816 246 0.786        
rs13212041        0.948 0.643 0.444 0.423 0.629 0.545 0.361
  G   160 0.258 160 0.256        
   AA 171 0.552 179 0.572        
   AG 118 0.381 108 0.345        
   GG 21 0.068 26 0.083        
  1. 1The allele for each SNP indicated is that with the higher patient frequency.
  2. 2The significance levels of chi-squared tests for codominant, dominant, recessive and overdominant model were adjusted using the Bonferroni correction (significance level p = 0.0036).
  3. 3The SNP allele that is observed at a higher frequency in patients is designated A; the other allele is designated a.