Skip to main content

Table 2 Allelic distributions of the 14 SNPs and their associations with schizophrenia

From: Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study

 

Case (n=310)

Control (n=313)

p Value2

SNP

Allele1

Genotype

No.

Frequency

No.

Frequency

Allele1

Codominant (AA/aa,Aa/aa,AA/Aa)3

Recessive

Dominant

Overdominant

rs4140535

      

0.725

0.806

1.000

0.729

0.909

0.684

0.764

 

T

 

394

0.635

391

0.625

       
  

CC

44

0.142

46

0.147

       
  

CT

138

0.445

143

0.457

       
  

TT

128

0.413

124

0.396

       

rs1778258

      

0.585

1.000

1.000

0.541

1.000

0.552

0.542

 

G

 

556

0.897

555

0.887

       
  

AA

4

0.013

4

0.013

       
  

AG

56

0.181

63

0.201

       
  

GG

250

0.806

246

0.786

       

rs17273700

      

0.423

0.772

0.377

0.185

0.576

0.279

0.184

 

T

 

554

0.894

550

0.879

       
  

CC

7

0.023

5

0.016

       
  

CT

52

0.168

66

0.211

       
  

TT

251

0.810

242

0.773

       

rs1228814

      

1.000

0.374

0.247

0.465

0.276

0.663

0.356

 

C

 

517

0.834

522

0.834

       
  

AA

13

0.042

8

0.026

       
  

AC

77

0.248

88

0.281

       
  

CC

220

0.710

217

0.693

       

rs11568817

      

0.315

1.000

1.000

0.254

1.000

0.271

0.255

 

T

 

559

0.902

553

0.883

       
  

GG

5

0.016

5

0.016

       
  

GT

51

0.165

63

0.201

       
  

TT

254

0.819

245

0.783

       

rs130058

      

0.916

0.686

0.816

0.434

1.000

0.449

0.816

 

T

 

49

0.079

48

0.077

       
  

AA

265

0.855

267

0.853

       
  

AT

41

0.132

44

0.141

       
  

TT

4

0.013

2

0.006

       

rs6297

      

0.409

0.599

0.786

0.565

0.788

0.460

0.816

 

A

 

541

0.873

536

0.856

       
  

AA

237

0.765

231

0.738

       
  

AG

67

0.216

74

0.236

       
  

GG

6

0.019

8

0.026

       

rs3827804

      

0.802

0.800

0.800

0.800

 

A

 

8

0.013

7

0.011

       
  

AG

8

0.026

7

0.022

       
  

GG

302

0.974

306

0.978

       
  

AA

0

0.000

0

0.000

       

rs140792648

      

0.862

0.860

0.860

0.860

 

 

604

0.974

608

0.971

       
  

—/—

294

0.948

295

0.942

       
  

—/AG

16

0.052

18

0.058

       
  

AG/AG

0

0.000

0

0.000

       

rs9361234

      

0.408

1.000

1.000

0.348

1.000

0.364

0.349

 

C

 

559

0.902

555

0.887

       
  

CC

254

0.819

247

0.789

       
  

CT

51

0.165

61

0.195

       
  

TT

5

0.016

5

0.016

       

rs183156887

      

1.000

1.000

1.000

1.000

 

A

 

4

0.006

4

0.006

       
  

AC

4

0.013

4

0.013

       
  

CC

306

0.987

309

0.987

       
  

AA

0

0.000

0

0.000

       

rs76194807

      

0.486

0.725

0.242

0.472

0.340

0.725

0.242

 

T

 

79

0.127

71

0.113

       
  

GG

234

0.755

247

0.789

       
  

GT

73

0.235

61

0.195

       
  

TT

3

0.010

5

0.016

       

rs58138557

      

0.411

1.000

1.000

0.351

1.000

0.367

0.352

 

GG

 

558

0.900

554

0.885

       
  

—/—

5

0.016

5

0.016

       
  

—/GG

52

0.168

62

0.198

       
  

GG/GG

253

0.816

246

0.786

       

rs13212041

      

0.948

0.643

0.444

0.423

0.629

0.545

0.361

 

G

 

160

0.258

160

0.256

       
  

AA

171

0.552

179

0.572

       
  

AG

118

0.381

108

0.345

       
  

GG

21

0.068

26

0.083

       
  1. 1The allele for each SNP indicated is that with the higher patient frequency.
  2. 2The significance levels of chi-squared tests for codominant, dominant, recessive and overdominant model were adjusted using the Bonferroni correction (significance level p = 0.0036).
  3. 3The SNP allele that is observed at a higher frequency in patients is designated A; the other allele is designated a.