TY - JOUR AU - Lam, Dilys AU - Ancelin, Marie-Laure AU - Ritchie, Karen AU - Freak-Poli, Rosanne AU - Saffery, Richard AU - Ryan, Joanne PY - 2018 DA - 2018/09/04 TI - Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression JO - BMC Psychiatry SP - 282 VL - 18 IS - 1 AB - Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA methylation at the promoter CpG island. Few studies have explored the influence of genetic variation across the gene on DNA methylation, and their combined association with depression risk. The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are associated with depression status. SN - 1471-244X UR - https://doi.org/10.1186/s12888-018-1850-4 DO - 10.1186/s12888-018-1850-4 ID - Lam2018 ER -