Table 2 Potential associations between SLC6A4 DNA methylation and genotype
CpG unit | Genetic variant | Average methylation (%) | p-valuea | ||
|---|---|---|---|---|---|
Major homozygote | Heterozygote | Minor homozygote | |||
3 | rs4251417 | GG (3.04) | GA (2.70) | AA (1.56) | 0.12 |
14.15 | rs4251417 | GG (2.26) | GA (1.72) | AA (1.67) | 0.095 |
16.17.18.19.20 | rs140700 | GG (7.14) | GA (5.73) | AA (4.92) | 0.019 |
| Â | rs6354 | AA (7.29) | AC (6.43) | CC (6.03) | 0.054 |
| Â | rs25531 | AA (7.06) | AG (5.74) | GG (8.44) | 0.007 |
21 | rs25528 | AA (3.54) | AC (4.55) | CC (4.94) | 0.007 |
| Â | rs4251417 | GG (4.03) | GA (3.17) | AA (3.06) | 0.085 |
| Â | rs6354 | AA (3.53) | AC (4.30) | CC (4.94) | 0.023 |
| Â | 5-HTTLPR | LL (3.85) | SL (4.03) | SS (4.55) | 0.077 |