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Table 3 Adjusted associations between depression and SLC6A4 promoter methylation, stratified by 5-HTTLPR or 5-HTTLPR/rs25531 genotype

From: Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression

CpG unit Genotype Variables Unadjusted Adjusteda
β(SE) p-value β(SE) p-value
21 5-HTTLPR (LL) Depression 0.24 (0.39) 0.026 0.28 (0.41) 0.016
   Female sex    − 0.092 (0.39) 0.39
   Age (yrs)    0.024 (0.036) 0.83
   Antidepressants    −0.15 (0.83) 0.18
  5-HTTLPR (SS) Depression −0.38 (0.52) 0.004 −0.44 (0.54) 0.001
   Female sex    −0.17 (0.58) 0.22
   Age (yrs)    −0.03 (0.068) 0.82
   Antidepressant    0.13 (0.96) 0.33
   Living alone    0.38 (0.69) 0.018
  5-HTTLPR/rs25531 (L’L) Depression 0.33 (0.49) 0.019 0.36 (0.53) 0.019
   Female sex    0.074 (0.48) 0.60
   Age (yrs)    −0.005 (0.057) 0.97
   Antidepressant    −0.093 (1.3) 0.54
  5-HTTLPR/rs25531 (S’S′) Depression −0.28 (0.49) 0.027 −0.30 (0.50) 0.023
   Female sex    −0.14 (0.49) 0.29
   Age (yrs)    −0.22 (0.59) 0.097
   Antidepressant    0.098 (0.87) 0.44
   Living alone    0.27 (0.60) 0.056
25.26 5-HTTLPR (SS) Depression −0.37 (1.58) 0.009 −0.31 (1.68) 0.038
   Sex    −0.26 (1.65) 0.068
   Age (yrs)    −0.076 (0.20) 0.60
   Antidepressant    −0.087 (3.06) 0.56
  5-HTTLPR/rs25531 (S’S′) Depression −0.37 (1.53) 0.006 −0.31 (1.52) 0.020
   Sex    −0.19 (1.46) 0.13
   Age (yrs)    −0.26 (0.18) 0.046
   Antidepressant    −0.11 (2.71) 0.39
  1. aAdjusted for age, sex and antidepressant use, plus confounding factors (see methods) which remained significant in the final models at p < 0.15