Depressive disorders among patients with gastric cancer in Taiwan: a nationwide population-based study

BMC Psychiatry

Table 3 Analyses of risk factors for depressive disorder in patients with gastric cancer

Predictive variables	Univariate analysis		Multivariate analysis^a
Predictive variables	HR (95% CI)	P value	HR (95% CI)	P value
Age ≥ 65	1.04 (0.89–1.21)	0.611
Sex (female)	1.41 (1.21–1.64)	< 0.001	1.46 (1.25–1.70)	< 0.001
Comorbidities
Diabetes mellitus	1.33 (1.12–1.57)	0.001	1.13 (0.94–1.35)	0.186
Hypertension	1.45 (1.24–1.68)	< 0.001	1.27 (1.07–1.52)	0.008
Heart failure	1.41 (1.12–1.77)	0.003	1.12 (0.87–1.43)	0.393
COPD	1.22 (1.03–1.44)	0.019	1.11 (0.93–1.32)	0.259
Chronic kidney disease	1.21 (0.97–1.51)	0.098	1.02 (0.81–1.28)	0.886
Cirrhosis	1.40 (0.99–1.98)	0.056	1.35 (0.95–1.91)	0.090
Autoimmune diseases	1.25 (0.92–1.68)	0.150
Cerebrovascular disease	1.44 (1.19–1.75)	< 0.001	1.22 (1.00–1.50)	0.053
Ischemic heart disease	1.30 (1.10–1.53)	0.002	1.06 (0.88–1.28)	0.558
Treatment^b
Surgery alone	1.03 (0.89–1.21)	0.673
Surgery with neoadjuvant and/or adjuvant chemoradiotherapy	1.11 (0.96–1.30)	0.167
Chemoradiotherapy without surgery	0.79 (0.57–1.10)	0.164

COPD chronic obstructive pulmonary disease
^aAll factors with P < 0.1 in univariate analyses were included in the Cox multivariate analysis
^bTreatment was analyzed as a time-dependent covariate in the Cox regression model

ISSN: 1471-244X