Prospective observational cohort study of ‘treatment as usual’ over four years for patients with schizophrenia in a national forensic hospital

Richter, Melanie S.; O’Reilly, Ken; O’Sullivan, Danny; O’Flynn, Padraic; Corvin, Aiden; Donohoe, Gary; Coyle, Ciaran; Davoren, Mary; Higgins, Caroline; Byrne, Orla; Nutley, Tina; Nulty, Andrea; Sharma, Kapil; O’Connell, Paul; Kennedy, Harry G.

doi:10.1186/s12888-018-1862-0

Table 5 Hayes Process Mediation Model 4 for 10,000 bootstrapped samples: Regression and mediation coefficients

From: Prospective observational cohort study of ‘treatment as usual’ over four years for patients with schizophrenia in a national forensic hospital

	Change in Y		C1: direct effect of X on Y before mediation		C2: direct effect of X on Y after mediation		A: indirect effect of X on Y mediated via M		B: direct effect of M on Y adjusted for X
	R ²	p	Unstandardized effect size	95% CI	Unstandardized effect size	95% CI	Unstandardized effect size	95% CI	Unstandardized effect size	95% CI
Total sample n = 69
Model A
X = MCCB	0.6241	0.0000	−0.0065	−0.0345, 0.0215	0.0307	− 0.0057, 0.0671	0.0372	0.0129, 0.0663	1.8406	1.3673, 2.3138
M = change D-3 mean	0.6241	0.0000	−0.0065	−0.0345, 0.0215	0.0307	− 0.0057, 0.0671	0.0372	0.0129, 0.0663	1.8406	1.3673, 2.3138
Model B
X = MCCB	0.6044	0.0000	0.0121	0.0019, 0.0223	0.0202	0.0064, 0.0340	0.0081	−0.0020, 0.0168	0.2637	0.1959, 0.3316
M = change HCR-C	0.6044	0.0000	0.0121	0.0019, 0.0223	0.0202	0.0064, 0.0340	0.0081	−0.0020, 0.0168	0.2637	0.1959, 0.3316
Less than 5 years n = 35
Model A
X = MCCB	0.6748	0.0000	−0.0338	−0.0758, 0.0081	0.0213	−0.0312, 0.0738	0.0551	0.0239, 0.0911	1.8597	1.1937, 2.5257
M = change D-3 mean	0.6748	0.0000	−0.0338	−0.0758, 0.0081	0.0213	−0.0312, 0.0738	0.0551	0.0239, 0.0911	1.8597	1.1937, 2.5257
Model B
X = MCCB	0.6768	0.0000	0.0237	0.0092, 0.0382	0.0296	0.0093, 0.0500	0.0059	−0.0075, 0.0199	0.2797	0.1795, 0.3799
M = change HCR-C	0.6768	0.0000	0.0237	0.0092, 0.0382	0.0296	0.0093, 0.0500	0.0059	−0.0075, 0.0199	0.2797	0.1795, 0.3799
More than 5 years n = 34
Model A
X = MCCB	0.6503	0.0000	0.0240	−0.0146, 0.0626	0.0419	−0.0144, 0.0981	0.0179	−0.0211, 0.0744	2.099	1.3878, 2.8104
M = change D-3 mean	0.6503	0.0000	0.0240	−0.0146, 0.0626	0.0419	−0.0144, 0.0981	0.0179	−0.0211, 0.0744	2.099	1.3878, 2.8104
Model B
X = MCCB	0.6315	0.0000	−0.0026	−0.0167, 0.0015	0.0085	−0.0115, 0.0285	0.0111	−0.0018, 0.0260	0.2653	0.1754, 0.3551
M = change HCR-C	0.6315	0.0000	−0.0026	−0.0167, 0.0015	0.0085	−0.0115, 0.0285	0.0111	−0.0018, 0.0260	0.2653	0.1754, 0.3551

Note: CI Confidence interval, MCCB MATRICS consensus cognitive battery, D-3 DUNDRUM-3 Programme Completion Scale mean total score, HCR-C History-Clinical-Risk Management-20 clinical items. In Model A the outcome variable (Y) was change in HCR-20 clinical items during the study. In Model B the outcome variable (Y) was change in DUNDRUM-3 Programme Completion Scale mean total score during the study. X, independent variable; M, mediator variable. All models were controlled for HCR-20 clinical baseline scores and DUNDRUM-3 mean total score at baseline
Model A: Y = HCR-20 clinical score change over four years. Model B: Y = DUNDRUM-3 mean total score change over four years; Results in bold are statistically significant

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ISSN: 1471-244X

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