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Table 2 Baseline characteristics of included trials

From: Comparative efficacy and safety between amisulpride and olanzapine in schizophrenia treatment and a cost analysis in China: a systematic review, meta-analysis, and cost-minimization analysis

Study Country Dosage range (mg/d) Sample size (Completed/All enrolled) F/U (weeks) Mean age(y) Gender (M, %) Diagnosis criteria Randomization Blinded Disease state Comorbidity
Amisulpride Olanzapine Amisulpride Olanzapine
Bhowmick 2010 [20] India 100–800 10–20 39/40 38/40 12 31.6 53.2% DSM-IV Y(computer-generated random number list) Single-blind / /
Chu 2015 [21] China 300–600 10–20 19/20 18/20 12 26.9 56.4% ICD-10 Y(random number table) N First episode /
Guo 2012 [22] China 600–1200 10–20 38/40 39/40 8 30.0 58.8% CCMD-3 Y(random number table) N / /
Kahn 2008 [23] Multiple countries 200–800 5–20 69/104 82/105 52 25.8 59.8% MINI plus Y(a dedicated web-based online system) N / /
Kong 2014 [24] China 400–1000 15–20 35/35 35/35 8 29.5 61.4% CCMD-3 Y(random digital coding) N First episode /
Lecrubier 2006 [18] France 150 20 67/70 64/70 24 37.0 72.9% DSM-IV Y double-blind chronic schizophrenia (≥1 yr) /
Li B 2015 [25] China 800 20 40/40 40/40 12 41.1 60.0% CCMD-3 Y(random number table) N First episode /
Li F 2014 [26] China 200–800 10–20 31/31 31/31 8 27.7 54.8% DSM-IV Y(random number table) N First episode /
Lin 2015 [27] China 600–800 10–20 30/32 31/32 8 31.3 100.0% ICD-10 Y N acute schizophrenia /
Liu 2015 [28] China 400–800 10–20 22/25 23/25 6 34.3 0.0% ICD-10 Y N / /
Lv 2014 [29] China 200–800 5–20 40/40 40/40 8 35.9 0.0% CCMD-3 Y(admission order) N / /
Mortimer 2004 [30] Multiple countries 200–800 5–20 117/189 125/188 24 37.8 65.0% DSM-IV Y(computer-generated random number list) double-blind acute schizophrenia /
Pawar 2012 [31] India 400–800 10–20 32/40 32/41 8 30.3 54.7% ICD-10 Y double-blind First episode /
Sun 2013 [32] China 800–1200 15–20 36/38 32/36 6 27.3 51.4% DSM-IV Y N acute schizophrenia /
Vanelle 2006 [33] Multiple countries 200–600 5–15 35/45 36/40 8 34.4 63.5% DSM-IV Y(computer-generated random number list) double-blind / Depression
Wagner 2005 [34] Germany 400–800 10–20 18/26 18/26 8 36.3 36.1% DSM-IV, ICD-10 Y(pseudo-random computer algorithm) double-blind / /
Yang D 2014 [35] China 200–1200 5–20 61/63 60/63 12 33.2 50.4% CCMD-3 Y(random number table) N / /
Yang F 2015 [36] China 100–300 10–20 42/42 43/43 12 36.1 49.4% ICD-10 Y N / /
Yao 2016 [37] China 800–1200 15–20 30/30 35/35 8 28.3 47.7% ICD-10 Y Single-blind First episode /
Yi 2014 [38] China max.1000 max. 20 29/30 30/30 8 70.4 55.0% DSM-IV Y(random number table) N / /
  1. Note: Included studies that published in English did not mention whether the amisulpride medication was generic or original, while five Chinese studies reported the information, all of which were generic
  2. F/U Follow up, DSM-IV Diagnostic and statistical manual of mental disorders, 4th edition, ICD-10 International statistical classification of diseases and related health problems 10th revision, CCMD-3 Chinese classification and diagnosis of mental diseases-3rd edition, MINI plus Mini international neuropsychiatric interview plus