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Table 4 Cost-minimization analysis comparing amisulpride and olanzapine in the treatment of Chinese patients with schizophrenia

From: Comparative efficacy and safety between amisulpride and olanzapine in schizophrenia treatment and a cost analysis in China: a systematic review, meta-analysis, and cost-minimization analysis

Data Input Amisulpride Olanzapine
Drug costs Mean Range Mean Range
 Unit drug cost – base case (CNY) 8.40 6.72–10.08 15.05 12.04–18.06
 Unit drug cost – scenario (CNY) 13.53 10.82–16.23 21.90 17.52–26.28
 Daily dosage (mg) 565.78 400.00–800.00 12.57 5.00–20.00
Probability of adverse events
 Probability of weight gain 0.15 0.12–0.18 0.40 0.32–0.48
 Probability of increased blood glucose levels 0.03 0.02–0.03 0.06 0.04–0.07
 Probability of liver function damage 0.06 0.04–0.07 0.13 0.1–0.16
 Probability of lactation/amenorrhea/sexual hormone disorder 0.09 0.07–0.11 0.03 0.02–0.03
Cost of adverse events (CNY) Mean Range Data Source
 Weight gain 29 23.2–34.8 KOL interviewa
 Increased blood glucose levels 2111 1688.8-2533.2 KOL interview
 Liver function damage 575 460–690 KOL interview
 Lactation/amenorrhea/sexual hormone disorder 352 281.6–422.4 KOL interview
  1. aKOL Key opinion leader