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Table 3 SNPs in significant genetic models associated with ASD risk

From: FADS1-FADS2 and ELOVL2 gene polymorphisms in susceptibility to autism spectrum disorders in Chinese children

SNPs Model genotype Control (243) Case (243) OR (95% CI) p p FDR
rs174546 overdominant C/C-T/T 133 (55.6) 136 (56.7) 1.00 0.82 0.82
T/C 106 (44.4) 104 (43.3) 0.96 (0.67–1.38)
rs174585 dominant G/G 199 (82.2) 210 (86.4) 1.00 0.2 0.375
A/G-A/A 43 (17.8) 33 (13.6) 0.73 (0.44–1.19)
rs498793 overdominant C/C-T/T 210 (87.5%) 207 (85.9%) 1.00 0.6 0.75
T/C 30 (12.5%) 34 (14.1%) 1.15 (0.68–1.95)
rs174602 overdominant T/T-C/C 145 (61.2) 157 (64.9) 1.00 0.4 0.667
C/T 92 (38.8) 85 (35.1) 0.85 (0.59–1.24)
rs174593 recessive T/T-C/T 241 (99.2) 243 (100) 1.00 0.095 0.204
C/C 2 (0.8) 0 (0) NA
rs526126 recessive C/C-G/C 203 (83.5) 224 (98.7) 1.00 < 0.0001 < 0.01*
G/G 40 (16.5) 3 (1.3) 0.07 (0.02–0.22)
rs174616 overdominant G/G-A/A 181 (74.5) 188 (77.7) 1.00 0.41 0.615
A/G 62 (25.5) 54 (22.3) 0.84 (0.55–1.27)
rs17606561 overdominant G/G-A/A 164 (67.8) 137 (56.4) 1.00 0.0096 0.036*
A/G 78 (32.2) 106 (43.6) 1.63 (1.12–2.36)
rs2236212 recessive C/C-G/C 212 (89.1) 210 (87.9) 1.00 0.68 0.729
G/G 26 (10.9) 29 (12.1) 1.13 (0.64–1.98)
rs3798712 overdominant A/A-G/G 151 (63.5) 160 (66.1) 1.00 0.54 0.736
G/A 87 (36.5) 82 (33.9) 0.89 (0.61–1.29)
rs953413 recessive A/A-G/A 241 (100) 232 (98.7) 1.00 0.039 0.098
G/G 0 (0) 3 (1.3) NA
rs3756963 overdominant T/T-C/C 161 (66.5) 133 (54.7) 1.00 0.0078 0.039*
C/T 81 (33.5) 110 (45.3) 1.64 (1.14–2.37)
rs10498676 recessive G/G-A/G 184 (77) 204 (85.7) 1.00 0.014 0.042*
A/A 55 (23) 34 (14.3) 0.56 (0.35–0.89)
rs6936315 overdominant T/T-C/C 141 (59.2) 149 (61.6) 1.00 0.6 0.692
C/T 97 (40.8) 93 (38.4) 0.91 (0.63–1.31)
rs9468304 overdominant A/A-G/G 143 (59.1) 110 (45.3) 1.00 0.0023 0.017*
G/A 99 (40.9) 133 (54.7) 1.75 (1.22–2.50)
  1. OR Odds ratio, CI confidence interval, pFDR FDR corrected p value,* p < 0.05, NA is not applicable