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Table 2 Association between use of acetaminophen by the mother during pregnancy and mental health outcomes at the age of 6 years (N = 3470)

From: Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

Outcomes Frequency of outcome according to use of acetaminophen during pregnancy N (%) Crude analysis Adjusted analysisa p-value for sex – use of acetaminophen interaction termb
Exposed
n (%)
Not exposed
n (%)
OR
(95% CI)
OR
(95% CI)
p
6 years old
 Total SDQ (score ≥ 17 pts) 102 (10.57) 271 (10.82) 0.97 (0.77–1.24) 1.15 (0.88–1.50) 0.313 0.454
 Emotional symptoms (score ≥ 5 pts) 137 (14.20) 335 (13.37) 1.07 (0.87–1.33) 1.15 (0.91–1.46) 0.232 0.046
 Conduct problems (score ≥ 4 pts) 119 (12.33) 396 (15.81) 0.75 (0.60–0.93) 0.86 (0.68–1.10) 0.222 0.572
 Hyperactivity/inattention (score ≥ 7 pts) 137 (14.20) 344 (13.73) 1.04 (0.84–1.29) 1.10 (0.87–1.39) 0.427 0.018
 Peer relationship problems (score ≥ 4 pts) 124 (12.85) 366 (14.61) 0.86 (0.69–1.07) 1.08 (0.85–1.38) 0.517 0.140
 Prosocial behavior (score ≤ 4 pts) 8 (0.83) 33 (1.32) 0.63 (0.29–1.36) 0.63 (0.27–1.49) 0.376 0.967
11 years old
 Total SDQ (score ≥ 17 pts) 138 (14.39) 342 (13.75) 1.06 (0.85–1.30) 1.19 (0.94–1.50) 0.157 0.811
 Emotional symptoms (score ≥ 5 pts) 213 (22.21) 473 (19.01) 1.22 (1.01–1.46) 1.20 (0.98–1.46) 0.078 0.313
 Conduct problems (score ≥ 4 pts) 108 (11.26) 343 (13.79) 0.79 (0.63–1.00) 0.93 (0.72–1.20) 0.561 0.264
 Hyperactivity/inattention (score ≥ 7 pts) 165 (17.21) 391 (15.72) 1.12 (0.91–1.36) 1.20 (0.96–1.49) 0.112 0.797
 Peer relationship problems (score ≥ 4 pts) 131 (13.66) 328 (13.18) 1.04 (0.84–1.30) 1.21 (0.95–1.53) 0.123 0.781
 Prosocial behavior (score ≤ 4 pts) 8 (0.83) 40 (1.61) 0.52 (0.24–1.10) 0.79 (0.36–1.75) 0.565 0.151
  1. aLogistic regression adjusted according to sex, maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol consumption during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal mood issue and use of other analgesics during pregnancy. N after adjustment: 3103. bp-values marked in bold denote statistically significant results