Skip to main content

Table 4 Association between use of acetaminophen by mother during pregnancy and mental health outcomes at the age of 11 years among boys (N = 1781) and girls (N =  1666)

From: Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

Outcomes Frequency of outcome according to use of acetaminophen during pregnancy N (%) Crude analysis Adjusted analysisa
Exposed
n (%)
Not exposed
n (%)
OR
(95% CI)
OR
(95% CI)
p
Boys
 Total SDQ (score ≥ 17 pts) 89 (17.05) 199 (15.81) 1.09 (0.83–1.44) 1.21 (0.89–1.64) 0.228
 Emotional symptoms (score ≥ 5 pts) 116 (22.22) 223 (17.71) 1.33 (1.03–1.71) 1.31 (0.99–1.73) 0.052
 Conduct problems (score ≥ 4 pts) 68 (13.03) 185 (14.69) 0.87 (0.64–1.17) 1.08 (0.77–1.51) 0.664
 Hyperactivity/inattention (score ≥ 7 pts) 115 (22.03) 252 (20.02) 1.13 (0.88–1.45) 1.25 (0.95–1.65) 0.115
 Peer relationship problems (score ≥ 4 pts) 78 (14.94) 191 (15.17) 0.98 (0.74–1.31) 1.16 (0.85–1.59) 0.339
 Prosocial behavior (score ≤ 4 pts) 3 (0.57) 25 (1.99) 0.29 (0.86–0.95) 0.47 (0.14–1.63) 0.234
Girls
 Total SDQ (score ≥ 17 pts) 49 (11.21) 143 (11.64) 0.95 (0.68–1.35) 1.16 (0.80–1.69) 0.426
 Emotional symptoms (score ≥ 5 pts) 97 (22.20) 250 (20.34) 1.12 (0.85–1.46) 1.08 (0.81–1.43) 0.624
 Conduct problems (score ≥ 4 pts) 40 (9.15) 158 (12.86) 0.68 (0.47–0.98) 0.77 (0.52–1.14) 0.192
 Hyperactivity/inattention (score ≥ 7 pts) 50 (11.44) 139 (11.31) 1.01 (0.72–1.43) 1.14 (0.79–1.64) 0.498
 Peer relationship problems (score ≥ 4 pts) 53 (12.13) 137 (11.15) 1.10 (0.78–1.54) 1.30 (0.90–1.89) 0.164
 Prosocial behavior (score ≤ 4 pts) 5 (1.14) 15 (1.22) 0.94 (0.34–2.59) 1.38 (0.47–4.07) 0.562
  1. aLogistic regression adjusted according to maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol comsumption during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal mood issue and use of other analgesics during pregnancy. N after adjustment: 1585 boys and 1494 girls