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Table 4 Association between use of acetaminophen by mother during pregnancy and mental health outcomes at the age of 11 years among boys (N = 1781) and girls (N =  1666)

From: Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

Outcomes

Frequency of outcome according to use of acetaminophen during pregnancy N (%)

Crude analysis

Adjusted analysisa

Exposed

n (%)

Not exposed

n (%)

OR

(95% CI)

OR

(95% CI)

p

Boys

 Total SDQ (score ≥ 17 pts)

89 (17.05)

199 (15.81)

1.09 (0.83–1.44)

1.21 (0.89–1.64)

0.228

 Emotional symptoms (score ≥ 5 pts)

116 (22.22)

223 (17.71)

1.33 (1.03–1.71)

1.31 (0.99–1.73)

0.052

 Conduct problems (score ≥ 4 pts)

68 (13.03)

185 (14.69)

0.87 (0.64–1.17)

1.08 (0.77–1.51)

0.664

 Hyperactivity/inattention (score ≥ 7 pts)

115 (22.03)

252 (20.02)

1.13 (0.88–1.45)

1.25 (0.95–1.65)

0.115

 Peer relationship problems (score ≥ 4 pts)

78 (14.94)

191 (15.17)

0.98 (0.74–1.31)

1.16 (0.85–1.59)

0.339

 Prosocial behavior (score ≤ 4 pts)

3 (0.57)

25 (1.99)

0.29 (0.86–0.95)

0.47 (0.14–1.63)

0.234

Girls

 Total SDQ (score ≥ 17 pts)

49 (11.21)

143 (11.64)

0.95 (0.68–1.35)

1.16 (0.80–1.69)

0.426

 Emotional symptoms (score ≥ 5 pts)

97 (22.20)

250 (20.34)

1.12 (0.85–1.46)

1.08 (0.81–1.43)

0.624

 Conduct problems (score ≥ 4 pts)

40 (9.15)

158 (12.86)

0.68 (0.47–0.98)

0.77 (0.52–1.14)

0.192

 Hyperactivity/inattention (score ≥ 7 pts)

50 (11.44)

139 (11.31)

1.01 (0.72–1.43)

1.14 (0.79–1.64)

0.498

 Peer relationship problems (score ≥ 4 pts)

53 (12.13)

137 (11.15)

1.10 (0.78–1.54)

1.30 (0.90–1.89)

0.164

 Prosocial behavior (score ≤ 4 pts)

5 (1.14)

15 (1.22)

0.94 (0.34–2.59)

1.38 (0.47–4.07)

0.562

  1. aLogistic regression adjusted according to maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol comsumption during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal mood issue and use of other analgesics during pregnancy. N after adjustment: 1585 boys and 1494 girls