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Table 4 Breakout of studies based on number of medication trials prior to rTMS use

From: A systematic literature review of the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) in non-treatment resistant patients with major depressive disorder

Number of medication trials Studies Comparator Outcomes/effect; study duration
≥2 medication trials Fregni F, et al. (2006) [24]   Higher response rate to rTMS therapy in patients who had a lower number of refractory treatment trials.
≤1 medication trial Huang M-L, et al. (2012) [26]; rTMS plus med vs. sham plus med Significantly higher number of improvers at 4 weeks with rTMS plus med.
Wang H-N, et al. (2017) [27]; rTMS plus med vs. med Significantly higher number in response and remission at 12 months with rTMS plus med.
Wang Y-M, et al. (2017) [28]; rTMS plus med vs. sham plus med Response and remission significantly higher in the rTMS + med
Yang H, et al. (2017) [29] rTMS plus med vs. sham plus med Response and remission significantly higher in the rTMS + med
≥2 medication trials vs. ≤1 medication trial Brakemeier E-L, et al. (2007) [30]; Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance Likelihood of response was higher in low treatment resistant patients
O’Reardon JP, et al. (2009) [25]; Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance Likelihood of response was 4X higher and statistically significantly different in low treatment resistant patients
Brakemeier E-L, et al. (2008) [31]; Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance Use of rTMS in low treatment resistant patients had a statistically significant effect on improved outcomes
Cohen RB, et al. (2010) [32]; Use of rTMS with Low (1 trial) vs. high (≥2 trials) medication treatment resistance Use of rTMS in low treatment resistant patients had a statistically significant effect on improved outcomes
Carpenter LL, et al. (2012); [33] Use of rTMS with Low (≤1 trial) vs. high (≥2 trials) medication treatment resistance Use of rTMS in low treatment resistant patients had a modest effect on improving outcomes.