Table 1 Summary of findings to evaluate the certainty of the evidence, using the GRADE methodology

Activities of daily living

SMD 0.16 SD more (0.80 lower to 1.12 more)

–

I 31 C 30 (2 RCTs)

⨁◯◯◯ VERY LOW^a,b,c

We are uncertain about the effect of DAT on activities of daily living.

Depression

SMD 0.48 SD lower (1.93 lower to 0.98 higher)

–

I 80 C 82 (4 RCTs)

⨁◯◯◯ VERY LOW^a,b,c,d

We are uncertain about the effect of DAT on depression.

Agitation

SMD 1.12 SD lower (2.67 lower to 0.43 higher)

–

I 86 C 87 (3 RCTs)

⨁◯◯◯ VERY LOW^a,b,c

We are uncertain about the effect of DAT on agitation.

Quality of life

SMD 0.16 SD higher (0.41 lower to 0.73 higher)

–

I 76 C 75 (3 RCTs)

⨁◯◯◯ VERY LOW^b,c,e

We are uncertain about the effect of DAT on quality of life.

Cognitive impairment

SMD 0.52 SD lower (1.33 lower to 0.30 higher)

I 12 C 12 (1 RCT)

⨁◯◯◯ VERY LOW^a,c

We are uncertain about the effect of DAT on cognitive impairment.

Apathy

SMD 2.10 SD higher (1.29 higher to 2.91 higher)

I 19 C 18 (1 RCT)

⨁◯◯◯ VERY LOW^a,c

We are uncertain about the effect of DAT on apathy.