|
Outcome
| |
Estimate of mean difference (95% CI)
|
t (df)
|
P
|
|---|
|
Quality of life (WHOQOL-BREFb)
|
|
Total score
|
6 months (T1)
|
0.69 (− 2.56 to 3.93)
|
0.42 (354)
|
0.678
|
|
12 months (T2)
|
3.88 (0.49 to 7.27)
|
2.25 (356)
|
0.025*
|
|
18 months (T3)
|
1.89 (− 1.53 to 5.31)
|
1.09 (356)
|
0.279
|
|
Domain 1;
|
6 months (T1)
|
0.41 (− 0.94 to 1.76)
|
0.60 (357)
|
0.549
|
|
Physical health
|
12 months (T2)
|
1.82 (0.42 to 3.23)
|
2.55 (361)
|
0.011*
|
|
18 months (T3)
|
0.68 (− 0.74 to 2.10)
|
0.95 (361)
|
0.345
|
|
Domain 2;
|
6 months (T1)
|
0.48 (− 0.43 to 1.40)
|
1.04 (354)
|
0.300
|
|
Psychological
|
12 months (T2)
|
0.87 (− 0.08 to 1.83)
|
1.79 (357)
|
0.074
|
|
18 months (T3)
|
0.82 (− 0.15 to 1.78)
|
1.66 (357)
|
0.098
|
|
Domain 3;
|
6 months (T1)
|
0.17 (− 0.46 to 0.79)
|
0.52 (353)
|
0.603
|
|
Social relationships
|
12 months (T2)
|
0.72 (0.07 to 1.37)
|
2.18 (356)
|
0.030*
|
|
18 months (T3)
|
0.44 (− 0.21 to 1.10)
|
1.33 (356)
|
0.186
|
|
Domain 4;
|
6 months (T1)
|
−0.37 (− 1.61 to 0.87)
|
−0.59 (355)
|
0.556
|
|
Environment
|
12 months (T2)
|
−0.01 (− 1.30 to 1.29)
|
−0.01 (357)
|
0.993
|
|
18 months (T3)
|
−0.01 (− 1.32 to 1.30)
|
−0.02 (357)
|
0.986
|
|
Anxiety (BAIc)
|
|
Total score
|
6 months (T1)
|
0.88 (− 2.37 to 4.12)
|
0.53 (352)
|
0.595
|
|
12 months (T2)
|
−1.31 (− 4.72 to 2.10)
|
−0.76 (355)
|
0.451
|
|
18 months (T3)
|
−0.27 (− 3.70 to 3.16)
|
−0.16 (355)
|
0.875
|
|
Depression (PHQ-9d)
|
|
Total score
|
6 months (T1)
|
0.09 (− 1.74 to 1.92)
|
0.10 (354)
|
0.921
|
|
12 months (T2)
|
0.09 (−1.82 to 2.01)
|
0.10 (358)
|
0.923
|
|
18 months (T3)
|
1.14 (− 0.79 to 3.08)
|
1.16 (358)
|
0.247
|
|
Empowerment (NELe)
|
|
Total score
|
6 months (T1)
|
5.41 (0.42 to 10.40)
|
2.13 (353)
|
0.034*
|
|
12 months (T2)
|
6.39 (1.19 to 11.59)
|
2.42 (355)
|
0.016*
|
|
18 months (T3)
|
0.00 (− 5.24 to 5.25)
|
0.00 (355)
|
0.999
|
|
Dimension 1;
|
6 months (T1)
|
1.26 (− 0.55 to 3.08)
|
1.37 (354)
|
0.172
|
|
Professional help
|
12 months (T2)
|
0.52 (−1.37 to 2.40)
|
0.54 (360)
|
0.590
|
|
18 months (T3)
|
−2.45 (− 4.35 to − 0.55)
|
−2.53 (361)
|
0.012*
|
|
Dimension 2;
|
6 months (T1)
|
0.78 (− 0.54 to 2.09)
|
1.16 (353)
|
0.245
|
|
Social support
|
12 months (T2)
|
1.07 (− 0.30 to 2.43)
|
1.54 (356)
|
0.125
|
|
18 months (T3)
|
1.27 (− 0.11 to 2.65)
|
1.82 (356)
|
0.070
|
|
Dimension 3;
|
6 months (T1)
|
1.88 (− 0.12 to 3.88)
|
1.84 (354)
|
0.066
|
|
Confidence and purpose
|
12 months (T2)
|
2.08 (− 0.01 to 4.16)
|
1.96 (356)
|
0.051
|
|
18 months (T3)
|
0.80 (−1.30 to 2.91)
|
0.75 (356)
|
0.452
|
|
Dimension 4;
|
6 months (T1)
|
1.19 (0.08 to 2.31)
|
2.11 (355)
|
0.036*
|
|
Connectedness
|
12 months (T2)
|
0.71 (− 0.44 to 1.87)
|
1.21 (358)
|
0.226
|
|
18 months (T3)
|
−0.11 (− 1.28 to 1.06)
|
−0.18 (358)
|
0.857
|
|
Dimension 5;
|
6 months (T1)
|
0.07 (− 0.85 to 1.00)
|
0.15 (354)
|
0.878
|
|
Self-management
|
12 months (T2)
|
0.98 (0.02 to 1.95)
|
2.01 (357)
|
0.045*
|
|
18 months (T3)
|
0.48 (−0.49 to 1.48)
|
0.97 (358)
|
0.332
|
|
Dimension 6;
|
6 months (T1)
|
0.30 (− 0.83 to 1.42)
|
0.52 (355)
|
0.604
|
|
Caring community
|
12 months (T2)
|
1.19 (0.02 to 2.36)
|
2.00 (358)
|
0.046*
|
|
18 months (T3)
|
0.15 (− 1.03 to 1.33)
|
0.25 (359)
|
0.802
|
- *Significant difference
- aAll estimates are adjusted for ‘partner status’ and ‘duration of current symptoms’
- bWHOQOL-BREF World Health Organisation Quality of Life, Brief version
- cBAI Beck Anxiety Inventory
- dPHQ-9 Patient Health Questionnaire
- eNEL Netherlands Empowerment List
