Fig. 1
a-c: Remission rates at endpoint in patients randomized to EMC or TAU. a: In relation to prior medication. a: MDD: Major depressive disorder; EMC: Early Medication Change; TAU: Treatment as usual; * difference in remission Chi2-Test (df = 1) bold if significant. TAU arm: remission in patients with prior medication (8.6%), remission in patients without prior medication 24.3% p = 0.017. Bonferroni-Holm corrected significance level p = 0.025. In the EMC Arm: remission in patients without prior medication 17.1%, remission in patients with prior medication 31.2%; Chi2 = 0.656; df = 1; p = 0.456, Bonferroni-Holm corrected significance level: p = 0.025. b: In relation to a recurrent course of MDD or first episode. b: MDD: Major Depressive Disorder; EMC: Early Medication Change; TAU: Treatment as usual; * difference in remission Chi2-Test (df = 1) bold if significant. TAU-arm: remission in patients with recurrent MDD 7.6%, patients with first episode 31% p = 0.009; Bonferroni-Holm corrected significance level: p = 0.025. EMC-arm: remission in patients with recurrent MDD 22.1%, patients with first episode 20.6% p = 0.028; Bonferroni-Holm corrected significance level: p = 0.025; n.s. c: In relation to the presence of atypical MDD. c: MDD: Major Depressive Disorder; EMC: Early Medication Change; TAU: Treatment as Usual; * significant difference in remission Chi2-Test (df = 1) bold if significant. TAU-arm: remission in patients with patients with atypical MDD 27.8%, patients without atypical features 8.1% p = 0.028; Bonferroni-Holm corrected significance level: p = 0.025, n.s. EMC-arm: remission in patients with patients with atypical MDD 20.6%, patients without atypical features 22.6% p = 0.558; Bonferroni-Holm corrected significance level: p = 0.025; n.s