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Table 1 Therapeutic strategies depending on comorbid anxiety disorder

From: Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental)

Comorbidity First intention Second intention Contra-indications
Obsessive-compulsive disorders - SSRI
- Psychotherapy in combination
- Imipraminic
- α2 Antagonist
- Association of two ATDs from different pharmacological class
- Potentiation with AAP
- Tianeptine
- Irreversible non selective MAOI
- First-generation antipsychotic
- Anticonvulsant
- Bupropion
Panic disorders - Imipraminic
- α2 Antagonist
- Association of ATDs
- Anticonvulsant
- First-generation antipsychotic
Social anxiety
Generalised anxiety disorder
Post-traumatic stress disorder
  1. AAP Atypical antipsychotic, ATD Antidepressant, MAOI monoamine oxidase inhibitor, SSRI Selective serotonin reuptake inhibitors; SNRI: Dual serotonin and norepinephrine reuptake inhibitors