Table 3 Changes on symptomatology during the study period (T0-T3), mean (sd)

T0 (n = 32)

T1 (n = 38)

T2 (n = 26)

T3 (n = 28)

Co-efficient (CI), treatment period (T1-T3)

p-value

Global Severity Index (GSI)

1.07 (0.49)

1.15 (0.44)

0.94 (0.56)

0.75 (0.67)

−0.385 (− 0.576, − 0.194)

< 0.001

Subscale – depression (DEP)

1.60 (0.79)

1.74 (0.62)

1.43 (0.88)

1.18 (0.93)

−0.574 (− 0.849, − 0.244)

0.004

Subscale – anxiety (ANX)

0.89 (0.72)

0.98 (0.73)

0.78 (0.67)

0.53 (0.73)

−0.377 (− 0.561, − 0.193)

< 0.001

T0 (n = 17)

T1 (n = 20)

T2 (n = 14)

T3 (n = 12)

Co-efficient (CI), treatment period (T1-T3)

p-value

Global Severity Index (GSI)

0.75 (0.48)

0.74 (0.33)

0.46 (0.27)

0.53 (0.36)

−0.236 (− 0.457, − 0.016)

0.036

Subscale – depression (DEP)

1.01 (0.75)

1.07 (0.67)

0.75 (0.56)

0.75 (0.55)

−0.363 (− 0.748, 0.022)

0.064

Subscale – anxiety (ANX)

0.58 (0.55)

0.52 (0.37)

0.21 (0.21)

0.36 (0.40)

−0.220 (− 0.431, − 0.009)

0.041

T0 (n = 11)

T1 (n = 15)

T2 (n = 8)

T3 (n = 9)

Co-efficient (CI), treatment period (T1-T3)

p-value

Global Severity Index (GSI)

0.73 (0.56)

0.76 (0.39)

0.41 (0.30)

0.49 (0.22)

−0.333 (− 0.581, − 0.085)

0.009

Subscale – depression (DEP)

1.06 (0.77)

1.13 (0.57)

0.75 (0.59)

0.88 (0.41)

−0.348 (− 0.725, 0.028)

0.070

Subscale – anxiety (ANX)

0.53 (0.51)

0.64 (0.47)

0.29 (0.35)

0.22 (0.16)

−0.433 (− 0.708, − 0.159)

0.002

T0 (n = 419)

T1 (n = 512)

T2 (n = 389)

T3 (n = 370)

Co-efficient (CI), treatment period (T1-T3)

p-value

Global Severity Index (GSI)

0.25 (0.27)

0.21 (0.25)

0.19 (0.21)

0.20 (0.25)

0.007 (−0.012, 0.026)

0.472

Subscale – depression (DEP)

0.33 (0.42)

0.27 (0.38)

0.27 (0.35)

0.28 (0.39)

0.027 (−0.005, 0.058)

0.096

Subscale – anxiety (ANX)

0.17 (0.27)

0.14 (0.28)

0.13 (0.24)

0.13 (0.23)

0.001 (−0.022, 0.023)

0.957