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Table 2 Characteristics of patients stratified by New York Heart Association functional class

From: Associations of mood symptoms with NYHA functional classes in angina pectoris patients: a cross-sectional study

Variables Total NYHA class I NYHA class II NYHA class III-IV p value
N = 443 N = 115 N = 261 N = 67
26.0% 58.9% 15.1%
Characteristic of patients
 Age,mean ± SD,y 63.9 ± 9.8 61.3 ± 9.3 64.0 ± 9.8 68.2 ± 9.5 <.001
 Male,sex,No.(%) 337(76.1) 85(73.9) 199(76.2) 53(79.1) 0.73
 Body mass index,mean ± SD,kg/m2 24.5 ± 3.1 24.5± 24.5 ± 3.0 24.6 ± 3.6 0.94
 Ejection Fraction,mean ± SD,% 59.3 ± 11.0 61.0 ± 8.2 N = 100 60.8 ± 12.3 N = 235 50.1 ± 16.1 N = 58 <.001
 Nt-ProBNP,median(interquartile),pg/mL 123(50–382) 88(37–234) N = 92 118(50–309) N = 228 733(133–3892) N = 49 <.001
 Creatinine Clearance,mean ± SD,ml/min 65.5 ± 21.7 69.5 ± 18.2 67.0 ± 22.2 53.0 ± 21.0 <.001
Type of angina pectoris,No.(%) 0.24
 Unstable angina pectoris 256(57.8) 65(56.5) 158(60.5) 33(49.3)  
 Stable angina pectoris 187(42.2) 50(43.5) 103(39.5) 34(50.7)  
Severity of coronary artery stenosis,No.(%) <.001
 1 93(21.0) 40(34.8) 46(17.6) 7(10.4)  
 2 82(18.5) 19(16.5) 54(20.7) 9(13.4)  
 3 268(60.5) 56(48.7) 161(61.7) 51(76.1)  
Mood symptoms
 Depression severity,No.(%) <.001
  Non-depressed 271(61.2) 79(68.7) 169(64.8) 23(34.3)  
  Mild depression symptom 123(27.8) 27(23.5) 66(25.3) 30(44.8)  
  Moderate or severe depression symptom 49(11.1) 9(7.8) 26(10.0) 14(20.9)  
 Somatic depressive symptom score,mean(SD) 3.05(2.87) 2.81(2.64) 2.79(2.76) 4.48(3.28) <.001
 Cognitive depressive symptom score,mean(SD) 1.36(1.98) 1.21(1.94) 1.20(1.76) 2.24(2.58) <.001
 Anxiety severity,No.(%) 0.99
  Non-anxious 316(71.3) 80(69.6) 186(71.3) 50(74.6)  
  Mild anxiety symptom 103(23.3) 30(26.1) 62(23.8) 11(16.4)  
  Moderate or severe anxiety symptom 24(5.4) 5(4.3) 13(5.0) 6(9.0)  
Social economic factors
 Education,No.(%) 0.83
  less than 6 years 115(26.0) 26(22.6) 69(26.4) 20(29.9)  
  7–9 years 126(28.4) 33(28.7) 75(28.7) 18(26.9)  
  10–12 years 97(21.9) 29(25.2) 52(19.9) 16(23.9)  
  more than 12 years 105(23.7) 27(23.5) 65(24.9) 13(19.4)  
 Marriage,No.(%) 0.57
  Married 412(93.0) 109(94.8) 240(92.0) 63(94.0)  
  Divorced or Widowed or Single 31(7.0) 6(5.2) 21(8.0) 4(6.0)  
Medical history,No.(%)
 Hypertension 276(62.3) 56(48.7) 173(44.8) 45(67.2) .003
 Diabetes mellitus 154(34.8) 28(24.3) 90(34.5) 36(53.7) <.001
 Prior PCI 167(37.7) 42(36.5) 93(35.6) 34(50.7) .069
 History of antidepressant treatment 17(3.8) 4(3.5) 9(3.4) 4(6.0) 0.61
Medication use,No.(%)
 ACEI or ARB 317(71.6) 76(66.1) 192(73.6) 49(73.1) 0.32
 β blocker 384(86.7) 95(82.6) 232(88.9) 57(85.1) 0.23
 Aldosterone receptor antagonist 42(9.5) 2(1.7) 14(5.4) 26(38.8) <.001
 Loop diuretic 47(10.6) 2(1.7) 16(6.1) 29(43.3) <.001
 Anticoagulant 20(4.5) 3(2.6) 12(4.6) 5(7.5) 0.31
 Antidepressant 9(2.0) 1(0.9) 6(2.3) 2(3.0) 0.55
  1. Abbreviation: PCI: percutaneous transluminal coronary intervention; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker