Mixed-effects analyses | Primary outcome (depression severity); Hedges’ g (95% CI) | Secondary outcome (response rates); responders/total n (95% CI) | Secondary outcome (remission rates); remitters/total n (95% CI) |
---|---|---|---|
Pooled weighted effects | |||
Mean (95% CI); k; n | |||
 DTMS (H1-coil) | 1.55 (1.17–1.94); k = 8; n = 183 | 24% (11–44%); k = 6; n = 143 (27/143) | 10% (6–17%); k = 6; n = 143 (13/143) |
 rTMS (F8-coil) | .97 (.70–1.25); k = 12; n = 168 | 31% (22–43%); k = 9; n = 128 (39/128) | 22% (14–33%); k = 6; n = 77 (15/77) |
 H1-coil vs. F8-coil | Q (df 1) = 9.32, p = .002* | Q (df 1) = 2.46, p = .116 | Q (df 1) = 4.46, p = .035* |
Heterogeneity statistics | |||
 DTMS (H1-coil) | Q (df 7) = 16.89, p = .018*; I2 = 58% | Q (df 5) = 14.13, p = .015*; I2 = 65% | Q (df 5) = 4.05, p = .543; I2 = 0% |
 rTMS (F8-coil) | Q (df 11) = 22.91, p = .018*; I2 = 52% | Q (df 8) = 10.67, p = .221; I2 = 25% | Q (df 5) = 3.68, p = .596; I2 = 0% |
Sensitivity analyses | |||
Open-label studies only | |||
 DTMS (H1-coil) | 1.67 (1.24–2.11); k = 7; n = 100 | 29% (12–53%); k = 5; n = 54 (14/54) | 15% (8–28%); k = 5; n = 54 (7/54) |
 rTMS (F8-coil) | .74 (.50–.98); k = 4; n = 78 | 30% (21–41%); k = 4; n = 78 (23/78) | 26% (16–41%); k = 3; n = 48 (12/48) |
 H1-coil vs. F8-coil | Q (df 1) = 19.14, p < .001* | Q (df 1) = .34, p = .559 | Q (df 1) = 1.76, p = .184 |
Add-on studies only | |||
 DTMS (H1-coil) | 1.77 (1.12–2.42); k = 5; n = 73 | 14% (2–62%); k = 3; n = 27 (3/27) | 10% (3–30%); k = 3; n = 27 (2/27) |
 rTMS (F8-coil) | .96 (.67–1.26); k = 11; n = 158 | 33% (24–44%); k = 8; n = 118 (38/118) | 23% (14–35%); k = 5; n = 67 (14/67) |
 H1-coil vs. F8-coil | Q (df 1) = 11.46, p = .001* | Q (df 1) = .52, p = .473 | Q (df 1) = 1.66, p = .197 |