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Table 2 ACC Metabolite Levels and Tissue Composition in the OCD and HC groups

From: Investigation of anterior cingulate cortex gamma-aminobutyric acid and glutamate-glutamine levels in obsessive-compulsive disorder using magnetic resonance spectroscopy

  OCD (n = 23) HC (n = 20)  
MRS metabolite Mean ± SD (iu+) Mean ± SD (iu) t(df) p
 GABA+ 2.41 ± 0.59 2.10 ± 0.35 2.05 (41) 0.047*
 Glx 2.10 ± 0.49 2.23 ± 0.38 −0.97 (41) 0.34
 GABA+/Glx Ratio 1.18 ± 0.30 0.96 ± 0.22 2.70 (41) 0.01*
Tissue composition Mean Percentage ± SD Mean ± SD t(df) p
 Cerebral spinal fluid 0.17 ± 0.02 0.16 ± 0.02 1.82 (41) 0.0781
 Gray matter 0.52 ± 0.03 0.52 ± 0.03 / 0.752
 White matter 0.31 ± 0.04 0.32 ± 0.03 1.59 (41) 0.3431
  1. +iu, institutional units; ACC anterior cingulate cortex, GABA gamma-aminobutyric acid, Glx glutamate-glutamine, MRS magnetic resonance spectroscopy, HC healthy control, OCD obsessive-compulsive disorder
  2. *significant between-group difference (p < 0.05)