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Table 1 Participant demographics, clinical data, blood tests, and EL concentration according to diagnosis

From: Association of plasma endothelial lipase levels on cognitive impairment

 

Total

control

MCI

AD

P-value

N

109

51

38

20

 

Age

75.3 ± 5.7

73.8 ± 4.9

75.3 ± 5.0

79.1 ± 7.2

0.002

Sex, male/female N (female %)

37/72 (66%)

10/41 (80%)

19/19 (50%)

8/12 (60%)

0.009*

Education, years

9.8 ± 4.7

9.4 ± 5.2

10.6 ± 3.9

9.2 ± 4.9

0.413

BMI

24.0 ± 2.7

24.2 ± 2.6

23.8 ± 2.7

24.0 ± 2.9

0.829

Total Protein (g/dL)

7.0 ± 0.5

7.1 ± 0.5

7.0 ± 0.4

6.8 ± 0.5

0.046

Albumin (g/dL)

4.3 ± 0.3

4.4 ± 0.3

4.4 ± 0.3

4.2 ± 0.3

0.010

Total Cholesterol (mg/dL)

177.0 ± 32.0

174.1 ± 30.2

175.8 ± 31.4

186.8 ± 37.3

0.312

HDL-C (mg/dL)

54.0 ± 16.5

56.9 ± 16.7

53.2 ± 16.4

50.1 ± 16.4

0.365

LDL-C (mg/dL)

108.9 ± 30.0

104.9 ± 30.2

109.3 ± 28.6

118.2 ± 31.3

0.246

Triglyceride (mg/dL)

149.3 ± 84.6

138.5 ± 62.4

152.0 ± 95.8

171.4 ± 108.2

0.330

ApoE4 carrier, N (%)

36 (33%)

11 (22%)

14 (37%)

11 (55%)

0.022*

Amyloid PET positive N (%)

40 (37%)

9 (18%)

18 (47%)

13 (65%)

<  0.001*

CDR

0.6 ± 0.5

0.4 ± 0.2

0.5 ± 0.1

1.5 ± 0.8

< 0.001*

CDR-SOB

2.4 ± 3.7

0.7 ± 0.4

1.5 ± 1.1

8.8 ± 4.7

< 0.001

MMSE

25.0 ± 5.3

27.6 ± 2.1

25.9 ± 2.7

16.6 ± 6.4

< 0.001

EL (ng/ml)

21.4 ± 10.1

21.0 ± 8.8

21.9 ± 9.7

21.7 ± 14.2

0.899

  1. The continuous value is represented by mean ± SD
  2. p-values are for the analysis of variance (ANOVA), * for chi-squared test of independence
  3. Abbreviation: BMI body mass index, HDL-C high density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoE, Apolipoprotein E; CDR, clinical dementia rating; CDR-SOB, clinical dementia rating scale sum of boxes, MMSE mini-mental state examination, EL endothelial lipase