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Table 2 Characteristics of acne vulgaris patients stratified according the depression

From: Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

  Patients without depression (n = 98) Patients with depression (n = 20) P-value a OR (95%CI) P-vlaue
Demographic variables (n (%))
 Age (yrs.) 20.98 ± 1.57 20.95 ± 1.36 0.99 1.12 (0.66–1.90) 0.743
 Gender (f/m) 40/48 11/9 0.149 1.33 (0.24–7.45) 0.743
 Graduate with no work (n) 14 (14) 7 (35) 0.027 11.05 (1.67–73.12) 0.013
 High family annual income (n) 64 (65) 5 (25) 0.001 7.71 (1.69–35.21) 0.008
 Family history of acne vulgaris (n) 18 (18) 8 (40) 0.033 0.82 (0.12–5.43) 0.837
 Disease durations (yrs.) 4 (3–6) 5.5 (4–7) 0.267 0.96 (0.67–1.38) 0.839
Medication variables
 Oral isotretinoin 40.82 55 0.210 0.64 (0.08–4.83) 0.663
 Oral antibiotics 36.73 45 0.488 1.18 (0.19–7.23) 0.857
Quality of life variables
 AIS 4.96 ± 3.06 9.10 ± 3.39 0.000 1.52 (1.17–1.98) 0.002
 GAGS 19.85 ± 6.85 21.85 ± 6.98 0.297 1.01 (0.85–1.19) 0.920
 DLQI 5.28 ± 4.34 8.55 ± 5.32 0.01 1.06 (0.88–1.28) 0.558
Laboratory findings
 BDNF (ng/ml) 13.85 ± 2.47 10.96 ± 2.12 0.000 0.52 (0.35–0.76) 0.001
 IL-6 (pg/ml) 36.18 ± 10.36 37.63 ± 8.89 0.247 1.02 (0.94–1.11) 0.671
 TNF- α (pg/ml) 453.40 ± 232.49 464.55 ± 177.27 0.493 1.00 (0.99–1.01) 0.830
  1. All data expressed as mean ± SD (range) of the mean of individual groups
  2. a Mann-whitney U test and chi-square test were used
  3. b Binary logistic regression was used
  4. Abbreviation: IQR interquartile range, PHQ-9:9-item Patient Health Questionnaire, AIS Athens Insomnia Scale, GAGS Global Acne Grading System, DLQI Dermatology Life Quality Index, BDNF brain-derived neurotrophic factor, IL-6 interleukin-6, TNF-α tumor necrosis factor-alpha