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Table 4 Linear regression analysis of the adjusted z scores of d′ on the Continuous Performance Test (CPT) in terms of treatment-resistant status with adjustments for covariates

From: Severity in sustained attention impairment and clozapine-resistant schizophrenia: a retrospective study

 

Undegraded CPT

Degraded CPT

Variables

Adjusted R2 = 0.1581

Adjusted R2 = 0.1874

β

(95% CI)

p

β

(95% CI)

p

Illness duration, years

−0.04

(−0.08–0.002)

0.0637

− 0.02

(− 0.05–0.005)

0.1104

Number of hospitalizations

0.06

(− 0.05–0.16)

0.2809

0.02

(− 0.05–0.09)

0.5195

CGI-S

0.04

(− 0.27–0.35)

0.7913

0.15

(− 0.07–0.36)

0.1810

Early onset, < 18 years

− 0.36

(− 1.18–0.46)

0.3872

−0.62

(−1.19 – − 0.04)

0.0351

Current cigarette-smoker

−0.31

(− 0.98–0.36)

0.3590

0.31

(− 0.15–0.78)

0.1868

Current antipsychotic dosage

− 0.0005

(− 0.002–0.001)

0.5001

−0.0006

(− 0.0016–0.0005)

0.3079

Atypical-antipsychotic-user

−0.07

(− 0.91–0.77)

0.8695

−0.16

(− 0.74–0.43)

0.5985

Treatment resistance status

 TRS without CR vs. non-TRS

−0.76

(− 1.69–0.18)

0.1120

−0.71

(− 1.36 – − 0.06)

0.0327

 TRS with CR vs. non-TRS

−2.25

(− 3.18 – − 1.32)

<  0.0001

− 1.53

(− 2.18 – − 0.88)

<  0.0001

  1. CPT continuous performance test, CGI-S Clinical Global Impression scale-Severity, TRS treatment-resistant schizophrenia, CR clozapine resistance, β parameter estimate, CI confidence interval