The humanistic and economic burden of treatment-resistant depression in Europe: a cross-sectional study

BMC Psychiatry

Table 2 Depression-related characteristics among respondents with TRD or nTRD

Parameters	TRD (n = 622)		nTRD (n = 2686)		P-value
Parameters	%	N	%	N	P-value
Family history of depression	47.7%	297	38.2%	1026	<0.001
Participation in talk therapy	33.3%	207	22.9%	616	<0.001
Anxiety	78.0%	485	61.6%	1654	<0.001
Suicide ideation	17.0%	106	8.2%	220	<0.001
Prescription medication use for depression
SSRI/SNRI/SARI/NaSSA	92.6%	576	90.0%	2417	<0.001
TeCA/TCA	21.9%	136	9.7%	261	<0.001
Benzodiazepine	11.3%	70	1.2%	32	<0.001
Anti-Psychotics	8.0%	50	1.0%	26	<0.001
NDRI/NRI	2.9%	18	0.9%	25	<0.001
MOAI/RIMA	1.0%	6	.0%	1	<0.001

MAOI Monoamine oxidase inhibitors, MDD major depressive disorder, nTRD non-treatment resistant depression, NA not applicable, NaSSA Noradrenergic and specific serotonergic antidepressant, NDRI Norepinephrine–dopamine reuptake inhibitors, NRI norepinephrine reuptake inhibitors, RIMA Reversible inhibitors of monoamine oxidase A, SD standard deviation, SSRI Selective serotonin reuptake inhibitors, SNRI Serotonin–norepinephrine reuptake inhibitors, TCA tricyclic antidepressants, TeCA tetracyclic antidepressants, TRD treatment resistant depression

ISSN: 1471-244X