From: Serum folate levels in bipolar disorder: a systematic review and meta-analysis
Author (year) | psychotropic medication use | proportion of specific medication | Healthy Control group criteria | dietary habit | nutritional status | genetic characteristics | Country |
---|---|---|---|---|---|---|---|
Doganavsargil Baysal, G.O. (2013) | yes | lithium: 11 patients (18.33%) valproic acid:6 patients (10%) mood stabilizing drugs plus antipsychotic drugs:30 patients (50%) two mood stabilizing drugs: 12 patients (20%) | Subjects who had not been diagnosed with a psychiatric disease and did not have a known significant medical condition or mental development disorder | n/a | n/a | n/a | Turkey |
Ezzaher, A. (2011) | yes | Valproic acid: 46 patients (50%) Lithium: 10 patients (10.9%) Carbamazepine: 9 patients (9.8%) Valproic acid and lithium: 3 patients (3.2%) Antipsychotics: 24 patients (26.1%) | None of the controls had psychiatric illnesses, epilepsy, mental retardation, hormone therapy, history of vitamin use, diabetes, cardiovascular disease, thyroid dysfunction, liver disease or renal dysfunction. | n/a | n/a | C677T MTHFR polymorphism was studied but no significant finding | Tunisia |
Diass, V.V. (2009) | yes | n/a | Healthy individuals were screened for personal and first-degree family axis I psychiatric disorders with the MINI. | n/a | n/a | n/a | Spain |
Ozbek, Z. (2008) | yes | Atypical antipsychotic: 17% typical antipsychotic: 65% atypical antipsychotic in combination with typical antipsychotic: 18% | Healthy and unrelated volunteers without psychiatric disorders were selected as a control group. | n/a | n/a | Patients carrying TT and/or AA and AC genotypes in methylenetetrahydrofolate (MTHFR) gene variants of c.1298A > C (Glu429Ala) and c.677C > T (Ala222Val) reduced folate levels | Turkey |
Lerner, V. (2006) | yes | n/a | Subjects from community clinics with no record of psychiatric illness | n/a | n/a | n/a | Israel |
Hasanah, C.I. (1997) | inpatient, n/a | n/a | The control group was taken from the out-patient clinic. Only patients with minor ailments like headaches, cough and cold were taken. Exclusion criteria for the control group were, family history and past history of psychiatric illness, substance misuse, recent weight loss, sleep disturbance, pregnancy and puerperium. | n/a | n/a | n/a | Malaysia |