From: Prepulse inhibition in patients with bipolar disorder: a systematic review and meta-analysis
Author (year) | Objective | Participants | Intervention | Outcome | Note |
---|---|---|---|---|---|
Matsuo, J. et al. 2018 [35] | To assess PPI deficits in patients with BD stratified by gender and disease status (euthymic/depressed). | 106 BD (63 with depression and 43 euthymic; 26 BD I and 80 BD II) and 232 control subjects. | All individuals were evaluated using the computerized startle reflex test unit, lead Interval of prepulse-pulse is 60 ms and 120 ms. | The male BD patients with depression had significant PPI deficits, female BD patients with psychosis show lower PPI. | qualitative synthesis |
QJ, Bo. et al. 2018 [36] | Using a perceived PSS-PPI paradigm to assess PPI levels in patients with BD. | 30 non-manic patients with BD and 33 HC | PPI was evaluated using a modified PSS-PPI paradigm, lead Interval of prepulse-pulse is 120 ms | Patients with BD exhibited PPI deficit by using PSS-PPI paradigm. PSS-PPI deficits was significantly associated with the language domain of RBANS. | qualitative synthesis |
Sanchez-Morla, E. M. et al. 2016 [16] | To assess PPI level in euthymic patients with BD. | 64 euthymic patients with BD and 64 control subjects | The acoustic startle measures of PPI were performed using 60-ms and 120-ms lead interval. | Compared with HC, BD patients showed PPI deficits that is related to social cognition | qualitative/quantitative synthesis |
Tamminga, C. A. et al. 2014 [37] | To assess SPEM, PPI, and ERP between schizophrenia and BD | 26 psychotic bipolar I disorder and 22 HC were tested for PPI level. | Standard clinical characterization and PPI (lead Interval, 120 ms) paradigm were applied. | PPI level did not differ between psychotic bipolar I disorder and HC. | qualitative synthesis |
Gogos, A. et al. 2009 [26] | To explore gender difference in PPI level in patients with BD. | 29 euthymic patients with BD, and 32 HC. | Two PPI stimulus onset asynchrony levels (60, 120 ms) were assessed by 21 pulse-alone trials (115 dB) and a total of 42 prepulse-pulse trials. | Compared with controls, the male patients with BD showed reduced PPI, whereas female patients had increased PPI levels. | qualitative/quantitative synthesis |
Carroll, C. A. et al. 2007 [29] | To assess PPI level in manic and mixed episode BD. | 14 manic patients with BD, 21 mixed episode patients with BD and 32 HC. | The acoustic startle measures of PPI were performed using a 120-ms lead interval. | Compared to HC, mixed episode patients exhibited less PPI latency facilitation, but PPI deficits were not observed across diagnostic groups (manic, mixed, control) | qualitative synthesis |
Giakoumaki, S. G. et al. 2007 [20] | To assess PPI level in remitted patients with BD and their unaffected siblings. | 21 patients with BD, 19 unaffected siblings and 17 HC | The tests of acoustic startle reactivity and PPI (lead Interval, 60 ms and 120 ms) of the startle response were investigated. | Patients with BD and their unaffected siblings showed PPI deficits, and had no significant correlation with symptom and disease severity. | qualitative/quantitative synthesis |
Barrett, S. L. et al. 2005 [28] | To assess PPI level in the euthymic phase of BD. | 23 euthymic patients with BD, and 20 HC. | The tests of acoustic startle reactivity and PPI of the startle response were performed. Lead interval of prepulse-pulse is 60 ms and 120 ms | There was no significant PPI deficits in the euthymic phase of BD. | qualitative/quantitative synthesis |
Rich, B. A. et al. 2005 [30] | To investigate PPI level in pediatric BD. | 16 patients with BD (medicated, euthymic and nonpsychotic), and 13 HC. | The magnitude of startle habituation, startle-alone response, and inhibition of startle following a 60 or 120-ms prepulse were evaluated. | Pediatric BD patients did not show PPI deficits compared to healthy controls. | qualitative/quantitative synthesis |
Braff, D. L. et al. 2001 [27] | To explore PPI level in BD patients with acute psychotic mania. | 15 patients with BD, 16 patients with schizophrenia and 17 HC | PPI (60 ms and 120 ms interstimulus intervals) was measured using Xeye Human startle reflex system. | Compared with HC, BD patients with acute psychotic mania had PPI deficits, and the extent of deficits was not significantly different from schizophrenia | qualitative synthesis |