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Table 1 Characteristics of included studies

From: Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

Study Year Country Ethnicity Gender Sample size OD (%) Control (%) HWE (P-value)
M W MM MW WW M W MM MW WW
Rs910080 (A/G)
 Yuanyuan et al. 2018 China Asian Both 541/566 14.3 85.7 22.2 24.2 73.6 13.2 86.8 1.6 23.1 75.3 0.77
 Nagaya et al. 2018 Malaysia Asian Male 459/543 16.1 83.9 34.9 25.3 71.2 12.4 87.6 2.4 20.1 77.5 0.07
 Hashemi et al. 2018 Iran Asian Both 216/219 43.1 56.9 19.9 46.3 33.8 30.1 69.9 3.2 53.9 52.9 <0.01
 Clarke et al. I 2012 USA Caucasian Both 1030/644 25.0 75.0 6.0 38.0 56.0 27.6 72.4 8.9 37.6 53.6 0.12
 Clarke et al. II 2012 USA African Both 330/663 46.8 53.2 23.0 47.6 29.4 48.2 51.8 22.8 50.8 26.4 0.64
 Wei et al. 2011 China Asian Both 304/301 21.9 78.1 4.9 33.9 61.2 15.3 84.7 1.3 27.9 70.8 0.18
 Jia et al. 2010 China Asian Both 212/200 23.6 76.4 3.3 40.6 56.1 25.7 74.3 4.5 42.5 53.0 0.12
Rs1997794(G/A)
 Yuanyuan et al. 2018 China Asian Both 541/566 16.4 83.6 2.0 28.7 69.3 15.5 84.5 1.9 27.0 71.0 0.42
 Nagaya et al. 2018 Malaysia Asian Male 459/543 48.2 51.8 22.7 51.2 23.1 50.9 49.1 26.0 49.9 24.1 0.97
 Clarke et al. I 2012 USA Caucasian Both 1037/652 35.0 65.0 11.7 46.6 41.8 37.9 62.1 15.3 45.1 39.6 0.28
 Clarke et al. II 2012 USA African Both 336/668 28.3 71.7 8.6 39.3 52.1 25.1 74.9 6.3 37.6 56.1 1.00
 Clarke et al. 2009 China Asian Female 119/176 19.3 80.7 3.4 31.9 64.7 11.4 88.6 0.6 21.6 77.8 0.34
Rs1022563(C/T)
 Nagaya et al. 2018 Malaysia Asian Male 459/543 17.9 82.1 3.9 27.9 68.2 17.6 82.4 3.3 28.6 68.1 0.72
 Clarke et al. I 2012 USA Caucasian Both 948/644 13.5 86.5 14.8 24.1 74.5 17.0 83.0 1.9 30.3 67.9 0.06
 Clarke et al. II 2012 USA African Both 336/660 21.6 78.4 5.1 33.0 61.9 18.9 81.1 3.0 31.8 65.2 0.35
 Wei et al. 2011 China Asian Both 304/300 16.3 83.7 3.9 24.7 71.4 17.0 83.0 0.7 32.7 66.7 <0.01
 Jia et al. 2010 China Asian Both 212/90 19.1 80.9 4.7 28.8 66.5 42.8 57.2 6.7 72.1 21.1 <0.01
 Clarke et al. 2009 China Asian Female 119/163 17.6 82.4 5.9 23.5 70.6 13.8 86.2 0 27.6 72.4 0.04
Rs2235749(T/C)
 Yuanyuan et al. 2018 China Asian Both 541/566 15.2 84.8 2.4 25.5 72.1 13.5 86.5 19.4 23.1 74.9 0.81
 Hashemi et al. 2018 Iran Asian Both 216/219 38.2 61.8 7.9 60.6 31.5 37.2 62.8 4.1 66.2 29.7 <0.01
 Wei et al. 2011 China Asian Both 304/300 21.9 78.1 5.3 33.2 61.5 15.3 84.7 1 28.7 70.3 0.07
 Jia et al. 2010 China Asian Both 212/200 18.6 81.4 4.7 27.8 67.5 27.3 72.8 14 26.5 59.5 <0.01
  1. OD opioid dependence, M mutant allele, W wild allele, HWE Hardy-Weinberg Equilibrium