Table 1 Characteristics of included studies
Study | Year | Country | Ethnicity | Gender | Sample size | OD (%) | Control (%) | HWE (P-value) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M | W | MM | MW | WW | M | W | MM | MW | WW | |||||||
Rs910080 (A/G) | ||||||||||||||||
Yuanyuan et al. | 2018 | China | Asian | Both | 541/566 | 14.3 | 85.7 | 22.2 | 24.2 | 73.6 | 13.2 | 86.8 | 1.6 | 23.1 | 75.3 | 0.77 |
Nagaya et al. | 2018 | Malaysia | Asian | Male | 459/543 | 16.1 | 83.9 | 34.9 | 25.3 | 71.2 | 12.4 | 87.6 | 2.4 | 20.1 | 77.5 | 0.07 |
Hashemi et al. | 2018 | Iran | Asian | Both | 216/219 | 43.1 | 56.9 | 19.9 | 46.3 | 33.8 | 30.1 | 69.9 | 3.2 | 53.9 | 52.9 | <0.01 |
Clarke et al. I | 2012 | USA | Caucasian | Both | 1030/644 | 25.0 | 75.0 | 6.0 | 38.0 | 56.0 | 27.6 | 72.4 | 8.9 | 37.6 | 53.6 | 0.12 |
Clarke et al. II | 2012 | USA | African | Both | 330/663 | 46.8 | 53.2 | 23.0 | 47.6 | 29.4 | 48.2 | 51.8 | 22.8 | 50.8 | 26.4 | 0.64 |
Wei et al. | 2011 | China | Asian | Both | 304/301 | 21.9 | 78.1 | 4.9 | 33.9 | 61.2 | 15.3 | 84.7 | 1.3 | 27.9 | 70.8 | 0.18 |
Jia et al. | 2010 | China | Asian | Both | 212/200 | 23.6 | 76.4 | 3.3 | 40.6 | 56.1 | 25.7 | 74.3 | 4.5 | 42.5 | 53.0 | 0.12 |
Rs1997794(G/A) | ||||||||||||||||
Yuanyuan et al. | 2018 | China | Asian | Both | 541/566 | 16.4 | 83.6 | 2.0 | 28.7 | 69.3 | 15.5 | 84.5 | 1.9 | 27.0 | 71.0 | 0.42 |
Nagaya et al. | 2018 | Malaysia | Asian | Male | 459/543 | 48.2 | 51.8 | 22.7 | 51.2 | 23.1 | 50.9 | 49.1 | 26.0 | 49.9 | 24.1 | 0.97 |
Clarke et al. I | 2012 | USA | Caucasian | Both | 1037/652 | 35.0 | 65.0 | 11.7 | 46.6 | 41.8 | 37.9 | 62.1 | 15.3 | 45.1 | 39.6 | 0.28 |
Clarke et al. II | 2012 | USA | African | Both | 336/668 | 28.3 | 71.7 | 8.6 | 39.3 | 52.1 | 25.1 | 74.9 | 6.3 | 37.6 | 56.1 | 1.00 |
Clarke et al. | 2009 | China | Asian | Female | 119/176 | 19.3 | 80.7 | 3.4 | 31.9 | 64.7 | 11.4 | 88.6 | 0.6 | 21.6 | 77.8 | 0.34 |
Rs1022563(C/T) | ||||||||||||||||
Nagaya et al. | 2018 | Malaysia | Asian | Male | 459/543 | 17.9 | 82.1 | 3.9 | 27.9 | 68.2 | 17.6 | 82.4 | 3.3 | 28.6 | 68.1 | 0.72 |
Clarke et al. I | 2012 | USA | Caucasian | Both | 948/644 | 13.5 | 86.5 | 14.8 | 24.1 | 74.5 | 17.0 | 83.0 | 1.9 | 30.3 | 67.9 | 0.06 |
Clarke et al. II | 2012 | USA | African | Both | 336/660 | 21.6 | 78.4 | 5.1 | 33.0 | 61.9 | 18.9 | 81.1 | 3.0 | 31.8 | 65.2 | 0.35 |
Wei et al. | 2011 | China | Asian | Both | 304/300 | 16.3 | 83.7 | 3.9 | 24.7 | 71.4 | 17.0 | 83.0 | 0.7 | 32.7 | 66.7 | <0.01 |
Jia et al. | 2010 | China | Asian | Both | 212/90 | 19.1 | 80.9 | 4.7 | 28.8 | 66.5 | 42.8 | 57.2 | 6.7 | 72.1 | 21.1 | <0.01 |
Clarke et al. | 2009 | China | Asian | Female | 119/163 | 17.6 | 82.4 | 5.9 | 23.5 | 70.6 | 13.8 | 86.2 | 0 | 27.6 | 72.4 | 0.04 |
Rs2235749(T/C) | ||||||||||||||||
Yuanyuan et al. | 2018 | China | Asian | Both | 541/566 | 15.2 | 84.8 | 2.4 | 25.5 | 72.1 | 13.5 | 86.5 | 19.4 | 23.1 | 74.9 | 0.81 |
Hashemi et al. | 2018 | Iran | Asian | Both | 216/219 | 38.2 | 61.8 | 7.9 | 60.6 | 31.5 | 37.2 | 62.8 | 4.1 | 66.2 | 29.7 | <0.01 |
Wei et al. | 2011 | China | Asian | Both | 304/300 | 21.9 | 78.1 | 5.3 | 33.2 | 61.5 | 15.3 | 84.7 | 1 | 28.7 | 70.3 | 0.07 |
Jia et al. | 2010 | China | Asian | Both | 212/200 | 18.6 | 81.4 | 4.7 | 27.8 | 67.5 | 27.3 | 72.8 | 14 | 26.5 | 59.5 | <0.01 |