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Table 3 Association between prodynorphin gene polymorphisms and opioid dependence

From: Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

Genetic model

Association

FDR

Effect model

Heterogeneity

OR

95% CI

P-value

I2 (%)

P-value

Rs910080

 Overall

  A vs. G

1.16

0.94–1.41

0.16

0.28

R

81

<0.01

  AA vs. GG

1.53

0.83–2.84

0.17

0.28

R

84

<0.01

  AG vs. GG

1.06

0.95–1.19

0.32

0.32

F

32

0.18

  AA + AG vs. GG

1.12

0.93–1.34

0.24

0.30

R

63

0.01

  AA vs. AG + GG

1.52

0.85–2.70

0.16

0.28

R

83

<0.01

Asian

  A vs. G

1.30

1.04–1.62

0.02

0.05

R

70

0.01

  AA vs. GG

2.21

0.96–5.09

0.06

0.07

R

76

<0.01

  AG vs. GG

1.17

1.01–1.36

0.04

0.07

F

7

0.37

  AA + AG vs. GG

1.25

1.04–1.51

0.02

0.05

F

40

0.15

  AA vs. AG + GG

2.13

0.94–4.83

0.07

0.07

R

76

<0.01

Rs1997794

 Overall

  G vs. A

1.02

0.85–1.22

0.87

0.94

R

72

0.01

  GG vs. AA

0.98

0.68–1.43

0.94

0.94

R

58

0.05

  GA vs. AA

1.06

0.94–1.20

0.36

0.94

F

20

0.29

  GG + GA vs. AA

1.07

0.89–1.30

0.46

0.94

R

55

0.06

  GG vs. GA + AA

0.95

0.69–1.31

0.77

0.94

R

52

0.08

 Asian

  G vs. A

1.06

0.76–1.46

0.74

0.74

R

78

0.01

  GG vs. AA

0.90

0.65–1.23

0.50

0.63

F

49

0.14

  GA vs. AA

1.10

0.91–1.32

0.34

0.63

R

51

0.13

  GG + GA vs. AA

1.16

0.82–1.63

0.41

0.63

R

68

0.04

  GG vs. GA + AA

0.89

0.68–1.17

0.41

0.63

F

39

0.20

Rs1022563

 Overall

  C vs. T

0.85

0.62–1.17

0.32

0.40

R

88

<0.01

  CC vs. TT

1.29

0.57–2.89

0.54

0.54

R

75

<0.01

  CT vs. TT

0.66

0.44–1.00

0.05

0.25

R

89

<0.01

  CC + CT vs. TT

0.71

0.47–1.07

0.11

0.28

R

89

<0.01

  CC vs. CT + TT

1.45

0.79–2.65

0.23

0.38

R

57

0.04

 Asian

  C vs. T

0.80

0.47–1.37

0.42

0.50

R

91

<0.01

  CC vs. TT

1.71

0.36–8.07

0.50

0.50

R

83

<0.01

  CT vs. TT

0.54

0.26–1.13

0.10

0.35

R

92

<0.01

  CC + CT vs. TT

0.60

0.29–1.25

0.17

0.35

R

93

<0.01

  CC vs. CT + TT

2. 04

0.66–6.27

0.21

0.35

R

69

0.02

Rs2235749

 T vs. C

1.04

0.74–1.46

0.83

0.83

R

83

<0.01

 TT vs. CC

1.34

0.42–4.25

0.62

0.83

R

85

<0.01

 TC vs. CC

1.09

0.92–1.30

0.32

0.83

F

2

0.38

 TT + TC vs. CC

1.05

0.78–1.41

0.75

0.83

R

64

0.02

 TT vs. TC + CC

1.34

0.43–4.16

0.61

0.83

R

85

<0.01

  1. SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, F fix-effect model, R random-effect model, FDR adjusted P-value for false discovery rate
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