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Table 3 Association between prodynorphin gene polymorphisms and opioid dependence

From: Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

Genetic model Association FDR Effect model Heterogeneity
OR 95% CI P-value I2 (%) P-value
Rs910080
 Overall
  A vs. G 1.16 0.94–1.41 0.16 0.28 R 81 <0.01
  AA vs. GG 1.53 0.83–2.84 0.17 0.28 R 84 <0.01
  AG vs. GG 1.06 0.95–1.19 0.32 0.32 F 32 0.18
  AA + AG vs. GG 1.12 0.93–1.34 0.24 0.30 R 63 0.01
  AA vs. AG + GG 1.52 0.85–2.70 0.16 0.28 R 83 <0.01
Asian
  A vs. G 1.30 1.04–1.62 0.02 0.05 R 70 0.01
  AA vs. GG 2.21 0.96–5.09 0.06 0.07 R 76 <0.01
  AG vs. GG 1.17 1.01–1.36 0.04 0.07 F 7 0.37
  AA + AG vs. GG 1.25 1.04–1.51 0.02 0.05 F 40 0.15
  AA vs. AG + GG 2.13 0.94–4.83 0.07 0.07 R 76 <0.01
Rs1997794
 Overall
  G vs. A 1.02 0.85–1.22 0.87 0.94 R 72 0.01
  GG vs. AA 0.98 0.68–1.43 0.94 0.94 R 58 0.05
  GA vs. AA 1.06 0.94–1.20 0.36 0.94 F 20 0.29
  GG + GA vs. AA 1.07 0.89–1.30 0.46 0.94 R 55 0.06
  GG vs. GA + AA 0.95 0.69–1.31 0.77 0.94 R 52 0.08
 Asian
  G vs. A 1.06 0.76–1.46 0.74 0.74 R 78 0.01
  GG vs. AA 0.90 0.65–1.23 0.50 0.63 F 49 0.14
  GA vs. AA 1.10 0.91–1.32 0.34 0.63 R 51 0.13
  GG + GA vs. AA 1.16 0.82–1.63 0.41 0.63 R 68 0.04
  GG vs. GA + AA 0.89 0.68–1.17 0.41 0.63 F 39 0.20
Rs1022563
 Overall
  C vs. T 0.85 0.62–1.17 0.32 0.40 R 88 <0.01
  CC vs. TT 1.29 0.57–2.89 0.54 0.54 R 75 <0.01
  CT vs. TT 0.66 0.44–1.00 0.05 0.25 R 89 <0.01
  CC + CT vs. TT 0.71 0.47–1.07 0.11 0.28 R 89 <0.01
  CC vs. CT + TT 1.45 0.79–2.65 0.23 0.38 R 57 0.04
 Asian
  C vs. T 0.80 0.47–1.37 0.42 0.50 R 91 <0.01
  CC vs. TT 1.71 0.36–8.07 0.50 0.50 R 83 <0.01
  CT vs. TT 0.54 0.26–1.13 0.10 0.35 R 92 <0.01
  CC + CT vs. TT 0.60 0.29–1.25 0.17 0.35 R 93 <0.01
  CC vs. CT + TT 2. 04 0.66–6.27 0.21 0.35 R 69 0.02
Rs2235749
 T vs. C 1.04 0.74–1.46 0.83 0.83 R 83 <0.01
 TT vs. CC 1.34 0.42–4.25 0.62 0.83 R 85 <0.01
 TC vs. CC 1.09 0.92–1.30 0.32 0.83 F 2 0.38
 TT + TC vs. CC 1.05 0.78–1.41 0.75 0.83 R 64 0.02
 TT vs. TC + CC 1.34 0.43–4.16 0.61 0.83 R 85 <0.01
  1. SNP single nucleotide polymorphism, OR odds ratio, CI confidence interval, F fix-effect model, R random-effect model, FDR adjusted P-value for false discovery rate