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Fig. 1 | BMC Psychiatry

Fig. 1

From: The impact of D-cycloserine and sarcosine on in vivo frontal neural activity in a schizophrenia-like model

Fig. 1

Spontaneous in vivo Ca2+ responses in the frontal cortex neurons and their sensitivity to NMDAR antagonist MK-801. a Sample image of neurons expressing CaMKII-GCaMP6s virus (green) in the frontal cortex. Scale bar, 10 μm. b Sample traces of spontaneous Ca2+ response before (baseline), 30 and 60 min after injection of MK-801 (0.3 mg/kg, i.p). Scale bars, 1 min; 4%ΔF/F0. c Quantification of Ca2+ responses and the effect of MK-801, 30 min after MK-801 injection. Dotted line indicates baseline levels, normalized to 100%. Amp, amplitude; Freq, frequency

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