Fig. 5

Effect of sarcosine on neural activity schizophrenia-like model mice. a. In neurons expressing synapsin-GCaMP6s virus, i. p. injection of sarcosine (A1; 0.3 g/kg; Rag, 104 somas/5 mice; Nrg1, 119 somas/4 mice) (A2; 1 g/kg; Rag, 94 somas/5 mice; Nrg1, 124 somas/4 mice) did not significantly change the amplitude, frequency or total activity of spontaneous Ca²⁺ responses, in either anti-Nrg1 or anti-Rag mice. Dotted line indicates baseline levels, normalized to 100%. b. In neurons expressing CaMKII-GCaMP6s virus, injection sarcosine (B1; 0.3 g/kg; Rag, 116 somas/4 mice; Nrg1, 60 somas/3 mice) (B2; 1 g/kg; Rag, 124 somas/5 mice; Nrg1, 85 somas/5 mice) did not significantly change the amplitude, frequency or total activity of Ca²⁺ responses, in either anti-Nrg1 or anti-Rag mice. Dotted line indicates baseline levels, normalized to 100%