Multimodal lifestyle intervention using a web-based tool to improve cardiometabolic health in patients with serious mental illness: results of a cluster randomized controlled trial (LION)

Table 2 Somatic outcomes after six and twelve months of lifestyle intervention in SMI patients. Results of general linear mixed models analyses with adjustment for AP medication side effect

	Waist circumference (N = 238)			BMI (N = 240)			Metabolic syndrome Z-score (N = 115)
	β	95% CI	p-value	β	95% CI	p-value	β	95% CI	p-value
Intervention effect^a
at 6 months^b	−0.15	[− 2.49; 2.19]	.90	0.27	[−0.32; 0.85]	.38	−0.25	[− 0.69;0.18]	.24
at 12 months^b	−1.03	[−3.42; 1.35]	.39	0.18	[−0.49; 0.86]	.60	−0.30	[−0.66; 0.05]	.09
Group difference (intervention vs control)	2.26	[−3.91; 8.44]	.45	1.47	[−0.17; 3.11]	.08	−0.10	[−0.54; 0.34]	.63
Time effect only
6 months	−0.15	[−1.84; 1.54]	.86	−0.15	[−0.57; 0.27]	.49	0.10	[−0.19; 0.40]	.48
12 months	1.56	[−0.23; 3.34]	.08	−0.26	[−0.77; 0.24]	.31	0.08	[−0.17; 0.33]	.51
AP med. Side effect^c
Medium	1.99	[−0.91; 4.90]	.18	0.90	[−0.01; 1.81]	.05	−0.07	[−0.51; 0.36]	.74
High	0.17	[−3.04; 3.38]	.92	0.08	[−1.09; 1.25]	.90	0.40	[0.00; 0.80]	.049

Abbreviations: AP medication side effect: antipsychotic medication side effect on metabolism; CI: confidence interval.
^a control group is reference
^b group x time
^c no AP medication side effect is reference
Bold p-values denote statistical significance at the p < 0.05 level

ISSN: 1471-244X