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Table 2 Somatic outcomes after six and twelve months of lifestyle intervention in SMI patients. Results of general linear mixed models analyses with adjustment for AP medication side effect

From: Multimodal lifestyle intervention using a web-based tool to improve cardiometabolic health in patients with serious mental illness: results of a cluster randomized controlled trial (LION)

  Waist circumference
(N = 238)
BMI
(N = 240)
Metabolic syndrome
Z-score (N = 115)
β 95% CI p-value β 95% CI p-value β 95% CI p-value
Intervention effecta
 at 6 monthsb −0.15 [− 2.49; 2.19] .90 0.27 [−0.32; 0.85] .38 −0.25 [− 0.69;0.18] .24
 at 12 monthsb −1.03 [−3.42; 1.35] .39 0.18 [−0.49; 0.86] .60 −0.30 [−0.66; 0.05] .09
Group difference (intervention vs control) 2.26 [−3.91; 8.44] .45 1.47 [−0.17; 3.11] .08 −0.10 [−0.54; 0.34] .63
Time effect only
 6 months −0.15 [−1.84; 1.54] .86 −0.15 [−0.57; 0.27] .49 0.10 [−0.19; 0.40] .48
 12 months 1.56 [−0.23; 3.34] .08 −0.26 [−0.77; 0.24] .31 0.08 [−0.17; 0.33] .51
AP med. Side effectc
 Medium 1.99 [−0.91; 4.90] .18 0.90 [−0.01; 1.81] .05 −0.07 [−0.51; 0.36] .74
 High 0.17 [−3.04; 3.38] .92 0.08 [−1.09; 1.25] .90 0.40 [0.00; 0.80] .049
  1. Abbreviations: AP medication side effect: antipsychotic medication side effect on metabolism; CI: confidence interval.
  2. a control group is reference
  3. b group x time
  4. c no AP medication side effect is reference
  5. Bold p-values denote statistical significance at the p < 0.05 level