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Table 2 Prevalence, severity and frequency of current schizophrenia symptoms

From: Patient characteristics, burden and pharmacotherapy of treatment-resistant schizophrenia: results from a survey of 204 US psychiatrists

  TRS
(n = 408)
Non-TRS
(n = 204)
p-value
Positive symptoms
Experiencing any, % (n) 84.6 (345) 64.2 (131) < 0.001
 Delusions 50.7 (207) 35.3 (72) < 0.001
 Hallucinatory behavior 46.1 (188) 24.5 (50) < 0.001
 Conceptual disorganization 24.3 (99) 17.2 (35) 0.046
 Excitement or agitation 11.8 (48) 9.8 (20) 0.47
 Hostility or aggression 11.5 (47) 4.9 (10) 0.008
Severity, mean (SD)a 3.0 (1.0) 2.5 (1.0) < 0.001
Experienced on a daily basis, % (n) 27.5 (95) 9.2 (12) < 0.001
Negative symptoms
Experiencing any, % (n) 73.3 (299) 61.8 (126) 0.004
 Blunted affect 37.0 (151) 30.9 (63) 0.14
 Emotional withdrawal 35.8 (146) 26.5 (54) 0.021
 Social withdrawal 30.1 (123) 21.6 (44) 0.025
 Poor rapport 16.2 (66) 14.2 (29) 0.53
Severity, mean (SD)a 3.0 (1.0) 2.4 (0.9) < 0.001
Experienced on a daily basis, % (n) 45.5 (136) 20.6 (26) < 0.001
Cognitive symptoms
Experiencing cognitive dysfunction, % (n) 37.3 (152) 24.0 (49) 0.001
Severity, mean (SD)a 3.0 (1.0) 2.5 (0.9) 0.002
Experienced on a daily basis, % (n) 61.2 (93) 36.7 (18) 0.003
  1. aSeverity rated 1 (minimal), 2 (mild), 3 (moderate), 4 (moderate–severe), 5 (severe), or 6 (extreme), for those patients experiencing symptoms
  2. SD standard deviation; TRS treatment-resistant schizophrenia
  3. p-values in bold are < 0.05