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Table 2 Prevalence, severity and frequency of current schizophrenia symptoms

From: Patient characteristics, burden and pharmacotherapy of treatment-resistant schizophrenia: results from a survey of 204 US psychiatrists

 

TRS

(n = 408)

Non-TRS

(n = 204)

p-value

Positive symptoms

Experiencing any, % (n)

84.6 (345)

64.2 (131)

< 0.001

 Delusions

50.7 (207)

35.3 (72)

< 0.001

 Hallucinatory behavior

46.1 (188)

24.5 (50)

< 0.001

 Conceptual disorganization

24.3 (99)

17.2 (35)

0.046

 Excitement or agitation

11.8 (48)

9.8 (20)

0.47

 Hostility or aggression

11.5 (47)

4.9 (10)

0.008

Severity, mean (SD)a

3.0 (1.0)

2.5 (1.0)

< 0.001

Experienced on a daily basis, % (n)

27.5 (95)

9.2 (12)

< 0.001

Negative symptoms

Experiencing any, % (n)

73.3 (299)

61.8 (126)

0.004

 Blunted affect

37.0 (151)

30.9 (63)

0.14

 Emotional withdrawal

35.8 (146)

26.5 (54)

0.021

 Social withdrawal

30.1 (123)

21.6 (44)

0.025

 Poor rapport

16.2 (66)

14.2 (29)

0.53

Severity, mean (SD)a

3.0 (1.0)

2.4 (0.9)

< 0.001

Experienced on a daily basis, % (n)

45.5 (136)

20.6 (26)

< 0.001

Cognitive symptoms

Experiencing cognitive dysfunction, % (n)

37.3 (152)

24.0 (49)

0.001

Severity, mean (SD)a

3.0 (1.0)

2.5 (0.9)

0.002

Experienced on a daily basis, % (n)

61.2 (93)

36.7 (18)

0.003

  1. aSeverity rated 1 (minimal), 2 (mild), 3 (moderate), 4 (moderate–severe), 5 (severe), or 6 (extreme), for those patients experiencing symptoms
  2. SD standard deviation; TRS treatment-resistant schizophrenia
  3. p-values in bold are < 0.05