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Table 2 Performance of AUDIT-C and biochemical markers for detecting alcohol use disorder

From: Identifying alcohol problems among suicide attempters visiting the emergency department

 

Alcohol use disorder*****

Men (N = 58)

Women (N = 30)

AUC

(95% CI)

SEN

(95% CI)

SPC

(95% CI)

LR+

LR−

Accuracy

(95% CI)

AUC

(95% CI)

SEN

(95% CI)

SPC

(95% CI)

LR+

LR−

Accuracy

(95% CI)

AST*

0.83

(0.74; 0.90)

87.9

(76.7; 95.0)

63.2

(46.0; 78.2)

2.39

0.19

0.77

(0.67; 0.85)

0.82

(0.73; 0.88)

76.7

(87.7; 90.1)

80.5

(69.9; 88.7)

3.94

0.29

0.79

(0.70; 0.86)

GGT*

0.85

(0.76; 0.91)

87.9

(76.7; 95.0)

63.2

(46.0; 78.2)

2.39

0.19

0.77

(0.67; 0.85)

0.81

(0.72; 0.88)

70.0

(50.6; 85.3)

83.1

(72.9; 90.7)

4.15

0.36

0.79

(0.71; 0.87)

CDT**

0.83

(0.74; 0.90)

81.0

(68.6; 90.1)

71.1

(54.1; 84.6)

2.80

0.27

0.76

(0.66; 0.84)

0.80

(0.71; 0.87)

70.0

(50.6; 85.3)

84.4

(74.4; 91.7)

4.49

0.36

0.79

(0.71; 0.87)

GGT–CDT***

0.86

(0.77; 0.92)

79.3

(66.6; 88.8)

76.3

(59.8; 88.6)

3.35

0.27

0.77

(0.67; 0.85)

0.86

(0.77; 0.92)

66.7

(47.2; 82.7)

93.5

(85.5; 97.9)

10.27

0.36

0.79

(0.71; 0.87)

AUDIT-C****

0.97

(0.91;0.99)

96.5

(88.1;99.6)

89.5

(75.2;97.1)

9.17

0.04

0.94

(0.87;0.98)

0.89

(0.81;0.94)

76.7

(57.7;90.1)

90.9

(82.2;96.3)

8.43

0.26

0.87

(0.79;0.93)

  1. *Cutoff points for AST and GGT are 40 U/L
  2. **Cutoff point for CDT – “all” group is 1.0%, “men” group is 1.0%, and “women” group is 0.8%
  3. ***Cutoff point for GGT–CDT – “all” group is 2.9308, “men” group is 3.0737, and “women” group is 2.2183
  4. ****Cutoff point for AUDIT-C – “all” group is score 4, “men” group is score 4, and “women” group is score 8. (The cutoff point was determined by ROC analyses in the sample)
  5. *****Alcohol use disorder (alcohol abuse or alcohol dependence in DSM-IV-TR)/reference population (not meet the substance use disorder criteria in DSM-IV-TR)
  6. AST = aspartic acid transaminase; AUC = area under the curve; AUDIT-C = Alcohol Use Disorder Identification Test Consumption; CDT = carbohydrate-deficient transferrin; GGT = gamma-glutamyltransferase; LR = likelihood ratios; SEN = sensitivity; SPC = specificity