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Table 2 cVEDA sample characterisation: Assessment domains, tools& protocols

From: Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol

Assessment domain

Questionnaires

6–11 years

12–17 years

18–23 years

Follow-up

Socio-demographic information

Socio-demographic questionnaire [89]

✓

✓

✓

✓

Migration questionnaire [90]

✓

✓

✓

✓

Exposures questionnaires

Environmental exposures questionnaire [91]

✓

✓

✓

✓

Adverse childhoodexperiences – International questionnaire [37]

✓

✓

✓

 

Children’s Revised Impact of Event Scale [92]

Short food questionnaire (modified Food Frequency Questionnaire) [93]

✓

✓

✓

 

Pregnancy History Instrument – Revised [94]

✓

✓

✓

 

Indian Family Violence and Control Scale [95]

✓

✓

✓

 

Mobile use questionnaire (Self-report) [96]

 

✓

✓

 

Mobile use questionnaire (Parent-report) –from the SCAMP study (https://www.scampstudy.org)

 

✓

  

Life Events Questionnaire [97]

  

✓

 

Questions on urbanicity (devised to explore all places a participant has successively resided at)

✓

✓

✓

 

Parenting

Alabama parenting questionnaire – Child & Parent [98, 99]

✓

✓

  

Adolescent attachment questionnaire [100]

 

✓

  

Parental bonding instrument [101]

  

✓

 

Temperament

Childhoodbehavior questionnaire [102]

✓

   

Early adolescent temperament questionnaire [103]

 

✓

  

Adult temperament questionnaire [104]

  

✓

 

Big Five Personality inventory [105]

  

✓

 

Strengths & difficulties questionnaire – Parent [106]

✓

✓

 

✓

Strengths & difficulties questionnaire – Child [107]

 

✓

 

✓

Strengths & difficulties questionnaire – Self-report [107]

  

✓

✓

Psychiatric morbidity

MINI-KID [108]

✓

✓

 

✓

MINI-5 [109]

  

✓

✓

ASSIST-Plus [110,111,112,113]

✓

✓

✓

✓

ASRS – ADHD [114]

  

✓

 

Family history

Family history questionnaire (clinical assessment for presence of medical and/or psychiatric disorders in first-degree relatives of the participant)

✓

✓

✓

 

Medical history

Medical problems questionnaire (clinical assessment for presence of medical disorders in the participant)

✓

✓

✓

 

Puberty

PubertalDevelopmentScale [115]

✓

✓

  

Neuropsychological assessment

Psychology Experiment Building Language (PEBL)[96]

✓

✓

✓

✓

 Digit span test – forward and reverse

 Corsi block test – forward and reverse

 Now or later test

 Trail making test

 Sort the cards

 Stop signal task [122]

Balloon analogue risk task [121]

Emotion recognition task

Social Cognition Rating Tool in the Indian Setting [116]

Anthropometry

Height

✓

✓

✓

✓

Weight

Mid arm circumference

Leg length

Head circumference

Neuroimaging

Structural MRI

✓

✓

✓

✓

 T1-weighted, 3D magnetization prepared gradient echo sequence (MPRAGE) based on the ADNI protocol (http://www.loni.ucla.edu/ADNI/Cores/index.shtml):

 T2 weighted fast- (turbo-) spin echo

 FLAIR scans

Diffusion MRI

 Single-shot spin-echo EPI sequence

  Single acquisition session

  Acquisition repeated with reversed blips

Resting state functional MRI

BOLD functional images acquired with a gradient- echoplanar imaging (EPI) sequence, using a relatively short echo-time to optimize reliable imaging of subcortical areas.

Toxicology

Urinary volatile organic compounds

✓

✓

✓

 

Solid phase extraction followed by High Performance Liquid Chromatography.

Urinary Arsenic

Flow injection system by Atomic

Absorption Spectrometer (PerkinElmer AA800, USA)

Plasma lead

Transversely-heated graphite furnace and Zeeman background correctionusing Graphite Furnace Atomic Absorption Spectrometer (PerkinElmer AA800, USA)