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Table 1 Prevalence of comorbidities in BPD of the interval 1996–2004 compared to the interval 2008–2012

From: Pharmacotherapy of borderline personality disorder: what has changed over two decades? A retrospective evaluation of clinical practice

 2008–2012 (N = 86)1996–2004 (N = 142) 
% (n)% (n)Fisher’s exact (p value)
substance related disorder55 (47)79 (112)0.0002
 alcohol47 (40)54 (76)0.3399
 cannabinoids24 (21)27 (38)0.7563
 sedatives and hypnotics9 (8)32 (45)< 0.0001
 opioids7 (6)10 (14)0.6300
adjustment and somatoform disorders40 (34)61 (86)0.0026
affective disorders31 (27)42 (60)0.1221
adjustment disorders or PTSD28 (24)40 (56)0.0868
anxiety and obsessive-compulsive disorder21 (18)20 (29)1.0000
eating disorder14 (12)34 (48)< 0.0001
behavioral disorder with somatic disturbances14 (12)22 (31)0.1641
emotional dysregulation in childhood10 (9)5 (7)0.1791
personality and behavioral disorder6 (5)27 (38)< 0.0001
  1. Rates in %; N number of patients with documented comorbidities. Bonferroni correction (p < 0.004). Significant p-values are highlighted in bold