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Table 8 Prevalence of psychotropic drugs at time of discharge (1996–2004 versus 2008–2012)

From: Pharmacotherapy of borderline personality disorder: what has changed over two decades? A retrospective evaluation of clinical practice

  Rates of psychotropic drugs1  
2008–2012 1996–2004
N = 87 N = 142 Fisher’s exact (p value)
antipsychotics 46 37.3 0.2139
antidepressants 67.8 56.3 0.0953
hypnotics / sedatives 24,1 24,6 10.000
mood stabilizers 9.2 24.6 0.0048
valproic acid 3.4 2.8  
carbamazepine 3.4 20.4  
lamotrigine 2.3 0  
naltrexone 35.6 6.3 < 0.0001
overall 94 71.8 < 0.0001
  Rates of antipsychotics2  
2008–2012 1996–2004
N = 40 N = 53 Fisher’s exact (p value)
low-potency antipsychotics 42.5 83 < 0.0001
high-potency antipsychotics 5 17 0.1073
second generation antipsychotics 60 43.3 0.1438
  Rates of antidepressants3  
2008–2012 1996–2004
N = 59 N = 80 Fisher’s exact (p value)
tri−/tetracyclic antidepressants 13.6 53.8 < 0.0001
SSRI 55.9 56.3 0.9702
MAO inhibitors 0 11.3  
atypical antidepressants 42.4 37.5 0.6013
  1. 1Rates in %; N number of patients of the cohort. Bonferroni correction (p < 0.008). Significant p-values are highlighted in bold
  2. 2Rates in %; reference is number of patients receiving antipsychotics (N). Bonferroni correction (p < 0.016). Significant p-values are highlighted in bold
  3. 3Rates in %; reference is number of patients receiving antidepressants (N). Bonferroni correction (p < 0.0125). Significant p-values are highlighted in bold