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Table 8 Prevalence of psychotropic drugs at time of discharge (1996–2004 versus 2008–2012)

From: Pharmacotherapy of borderline personality disorder: what has changed over two decades? A retrospective evaluation of clinical practice

 

Rates of psychotropic drugs1

 

2008–2012

1996–2004

N = 87

N = 142

Fisher’s exact (p value)

antipsychotics

46

37.3

0.2139

antidepressants

67.8

56.3

0.0953

hypnotics / sedatives

24,1

24,6

10.000

mood stabilizers

9.2

24.6

0.0048

valproic acid

3.4

2.8

 

carbamazepine

3.4

20.4

 

lamotrigine

2.3

0

 

naltrexone

35.6

6.3

< 0.0001

overall

94

71.8

< 0.0001

 

Rates of antipsychotics2

 

2008–2012

1996–2004

N = 40

N = 53

Fisher’s exact (p value)

low-potency antipsychotics

42.5

83

< 0.0001

high-potency antipsychotics

5

17

0.1073

second generation antipsychotics

60

43.3

0.1438

 

Rates of antidepressants3

 

2008–2012

1996–2004

N = 59

N = 80

Fisher’s exact (p value)

tri−/tetracyclic antidepressants

13.6

53.8

< 0.0001

SSRI

55.9

56.3

0.9702

MAO inhibitors

0

11.3

 

atypical antidepressants

42.4

37.5

0.6013

  1. 1Rates in %; N number of patients of the cohort. Bonferroni correction (p < 0.008). Significant p-values are highlighted in bold
  2. 2Rates in %; reference is number of patients receiving antipsychotics (N). Bonferroni correction (p < 0.016). Significant p-values are highlighted in bold
  3. 3Rates in %; reference is number of patients receiving antidepressants (N). Bonferroni correction (p < 0.0125). Significant p-values are highlighted in bold