Sexual dimorphism in up-regulation of suppressors of cytokine signaling genes in patients with bipolar disorder

BMC Psychiatry

Table 6 The results of ROC curve analysis (a: Youden index, b: Significance Level P (Area = 0.5), Estimate criterion: optimal cut-off point for gene expression)

	Estimate criterion	AUC	J^a	Sensitivity	Specificity	P-value^b
SOCS1	≤ 1.5	0.65	0.26	62	64	0.005
SOCS2	≤ 1.3	0.78	0.46	84	62	< 0.0001
SOCS3	≤ 1.3	0.72	0.32	72	60	< 0.0001
SOCS5	≤ 0.3	0.92	0.74	90	84	< 0.0001
Combination of four genes	> 0.54	0.93	0.8	88	92	< 0.0001

ISSN: 1471-244X