Fig. 2

Sunburst of treatment patterns starting with first line (inner-most donut) to fourth line (outer slices). Each color represents a distinct treatment class, and each layer repesents a new treatment line and illustrate the sequence in which patients received different therapies; for example the large orange piece in the middle indicates first-line SSRI use, and the pink slice on the next outter ring adjacent to the orange indicates a switch from an SSRI to an anxiolytic. Slices that have multiple colors indicate combination therapy with more than one medication class. Slices in grey indicate no additional medication was taken. Abbreviations: CCAE, IBM MarketScan® Commercial Database; MDCD, IBM MarketScan® Multi-State Medicaid Database; MDCR, IBM MarketScan® Medicare Supplemental Database; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor