Fig. 1

Manhattan plot shows p-value for stratified opioid users versus normal controls using FaST-LMM analysis. The X-axis represents the SNP markers in each chromosome and Y-axis represent the negative logarithm of P-values. The highest p-values were observed for rs118129027(p-value = 1.236 X 10 − 8) and rs74477937 (p-value = 1.485 X 10 − 8) on chromosome 7. The circle indicates a candidate haplotype that associated with opioid use disorder