Fig. 4

Receiver operating characteristic (ROC) curve discriminated MDD patients from HCs by evaluating Z scores of rsFC with significant between-group differences; enhanced accuracy was noted with a larger area under the curve (AUC). With the CA seed region, L-PMC: the left premotor cortex (AUC:0.76; cutoff: sensitivity:0.60; specificity:0.84); R-insula: the right insula (AUC:0.75; cutoff: sensitivity:0.96; specificity:0.48). With the DG seed region, L-vlPFC: the left ventrolateral prefrontal cortex (AUC:0.76; cutoff: sensitivity:0.55; specificity:0.92); L-OFC: the left orbitofrontal cortex (AUC:0.82; cutoff: sensitivity:0.75; specificity:0.88). With the subiculum seed region, L-vlPFC: the left ventrolateral prefrontal cortex (AUC:0.77; cutoff: sensitivity:0.40; specificity:0.92); R-MFG: the right middle gyrus (AUC:0.77; cutoff: sensitivity:0.64; specificity:0.92); L-PMC: the left premotor cortex (AUC:0.79; cutoff: sensitivity:0.86; specificity:0.56); R-insula: the right insula (AUC:0.76; cutoff: sensitivity:0.92; specificity:0.54)